化疗源性卵巢早衰的发生机制及中医药防治的研究进展

随着化疗在癌症中的广泛应用,患者的生存率大大提高.然而,抗癌治疗往往也是导致卵巢早衰(premature ovarian failure,POF)的重要原因.目前认为,化疗药物可以通过诱导卵巢细胞凋亡、加速原始卵泡激活、增加卵巢微血管损伤而导致原始卵泡池(primordial follicles,PMFs)减小,进而引...

Research progress on the mechanism of chemotherapy-induced premature ovarian failure and the prevention and treatment with traditional Chinese medicine

With the widespread use of chemotherapy in cancer, the survival rate of patients has been greatly improved.However, anticancer therapy is often also an important cause of premature ovarian failure(POF). At present, it is believed that chemotherapeutic drugs can lead to the reduction of primordial follicles(PMFs) by inducing ovarian cell apoptosis, accelerating primordial follicle activation, and increasing ovarian microvascular injury, which in turn triggers POF and infertility. The western medicine pathogenesis of chemotherapy-induced POF is complex, but traditional Chinese medicine can also be treated from "deficiency" and "blood stasis". By summarizing and sorting out the relationship between chemotherapeutic drugs and ovarian injury,the use of modern science and technology to develop traditional Chinese medicine is essential for the prevention of POF and the protection of female fertility.