中药调控色氨酸-肠道菌群代谢治疗溃疡性结肠炎的研究进展

溃疡性结肠炎(ulcerative colitis,UC)是一种慢性、易复发的炎症性肠病,临床上以血性腹泻、腹痛等为特征症状.UC的发病机制与肠黏膜免疫异常、肠道菌群失调、色氨酸代谢紊乱等密切相关.色氨酸-肠道菌群代谢能促进机体肠道免疫功能的发育和完善,因而对缓解肠道炎症具有重要意义.中医药在治疗UC方面具有一定的特色...

Research progress on traditional Chinese medicine regulating tryptophan-gut microbiota metabolism in the treatment of ulcerative colitis

Ulcerative colitis(UC) is a chronic, recurring inflammatory bowel disease, clinically characterized by bloody diarrhea and abdominal pain. The pathogenesis of UC is closely related to abnormal intestinal mucosal immunity, imbalance of gut microbiota,and tryptophan metabolism disorder. The tryptophan-gut microbiota metabolism can promote the development and perfection of the body’s intestinal immune function, so it is of great significance to alleviate intestinal inflammation. Traditional Chinese medicine has characteristics advantages in UC treatment. Many single herb and traditional Chinese medicine compound were proved having obvious effect of immunological regulation. In this review, we focused on the effects of tryptophan-gut microbiota metabolism on intestinal mucosal barrier function and immune function in UC, and the research progress of traditional Chinese medicine on regulating tryptophan-gut microbiota metabolism for the treatment of UC, with a view to providing references for mechanistic studies of traditional Chinese medicine for the treatment of UC and the development of new drugs.