穴位贴敷治疗过敏性哮喘患儿的疗效观察

【目的】观察穴位贴敷治疗过敏性哮喘患儿的临床疗效。【方法】将128例过敏性哮喘患儿随机分为观察组和对照组,每组各64例,对照组给予雾化吸入布地奈德混悬液及口服孟鲁司特片治疗,观察组在对照组治疗的基础上,给予穴位贴敷治疗,2组均连续治疗2周。治疗2周后,评价2组患儿的临床疗效,观察2组患儿治疗前后1 s用力呼气容积(FEV1)、最大呼气流量(PEF)、1 s用力呼气容积(FEV1)/用力肺活量(FVC)值的变化情况,以及血清总免疫球蛋白E(TlgE)、免疫球蛋白G4(lgG4)、嗜酸细胞阳离子蛋白(ECP)水平和呼出气一氧化氮(FeNO)含量的变化情况。比较2组患者治疗前后中医证候评分与儿童哮喘控制测试问卷(C-ACT)评分的变化情况。【结果】(1)观察组总有效率为95.31%(61/64),对照组为84.38%(54/64)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患儿的中医证候积分明显改善(P<0.05),且观察组在改善中医证候积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患儿的FeNO、TlgE、lgG4、ECP水平均明显改善(P<0.05),且观察组在改善FeNO、TlgE、lgG4、ECP水平方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗后,2组患儿的FEV1、FVC、FEV1/FVC水平均明显改善(P<0.05),且观察组在改善FEV1、FVC、FEV1/FVC水平方面均明显优于对照组,差异均有统计学意义(P<0.05)。(5)治疗后,2组患儿的C-ACT评分均明显改善(P<0.05),且观察组在改善C-ACT评分方面均明显优于对照组,差异均有统计学意义(P<0.05)。【结论】穴位贴敷治疗过敏性哮喘,能有效改善患儿临床症状,改善FeNO,血清TlgE、lgG4、ECP和肺功能等指标,控制哮喘复发,疗效显著。

Observation on Therapeutic Effect of Acupoint Application in Children with Allergic Asthma

Objective To observe the clinical efficacy of acupoint application in children with allergic asthma.Methods A total of 128 children with allergic asthma were randomly divided into observation group and control group,with 64 cases in each group. The control group was treated with inhaled Budesonide suspension and oral use of Montelukast tablets,and the observation group was treated with acupoint application on the basis of the treatment in the control group. Both groups were treated for two consecutive weeks. After two weeks of treatment,the clinical efficacy of two groups was evaluated, and the changes of forced expiratory volume in one second(FEV1)of one second before and after treatment,peak expiratory flow(PEF),FEV1/forced vital capacity(FVC)were observed. The changes of serum total immunoglobulin E(TlgE),immunoglobulin G4(lgG4),eosinophil cationic protein(ECP)levels and fractional exhaled nitric oxide(FeNO)were measured. The changes of tradition Chinese medicine(TCM)syndrome scores and Childhood Asthma Control Test(C-ACT)score were compared between the two groups before and after treatment. Results (1)The total effective rate was 95.31%(61/64)in the observation group and 84.38%(54/64)in the control group. The curative effect of observation group was superior to that of the control group, and the difference was statistically significant(P<0.05).(2)After treatment, TCM syndrome scores of two groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving TCM syndrome scores,the difference being statistically significant(P<0.05).(3)After treatment, the levels of FeNO, TlgE, lgG4 and ECP in the two groups were significantly improved(P<0.05), and the improvement of FeNO, TlgE, lgG4 and ECP in the observation group was significantly superior to that in the control group,and the differences were statistically significant(P<0.05).(4)After treatment,the levels of FEV1,FVC and FEV1/FVC in the two groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the levels of FEV1,FVC and FEV1/FVC,the difference being statistically significant(P<0.05).(5)After treatment,C-ACT scores in both groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving C-ACT scores, the difference being statistically significant(P<0.05). Conclusion Acupoint application in the treatment of allergic asthma has significant effect in improving the clinical symptoms,FeNO,serum TlgE,lgG4 and ECP,and pulmonary function of child patients,and the recurrence of asthma can be effectively controlled.