二周和三周多西紫杉醇方案治疗去势耐药前列腺癌的耐受性比较

目的 探讨2周和3周多西紫杉醇方案治疗去势耐药前列腺癌(CRPC)的耐受性比较.方法 选取2016年1月至2018年12月间辽阳市中心医院收治的52例CRPC患者,采用随机数表法分为2周组和3周组,每组26例.2周组患者采用多西紫杉醇2周方案,3周组患者采用多西紫杉醇3周方案,持续治疗至病情进展或出现无法耐受的不良反应...

Comparison of the tolerance of 2 weeks and 3 weeks regimen of docetaxel in the treatment of castration-resistant prostate cancer

Objective To compare the tolerance of 2 weeks and 3 weeks regimen of docetaxel in the treatment of castrate-resistant prostate cancer(CRPC). Methods Fifty-two CRPC patients who were treated at Liaoyang Central Hospital were selected from January 2016 to December 2018,and the patients were divided into a 2-week docetaxel group and a 3-week docetaxel group with 26 patients each using a random number table. The treatment continued until condition progresses or an intolerable adverse reaction occurred. Time to treatment failure,prostate specific antigen(PSA) response rate,≥ grade 3 leukopenia rate,and febrile neutropenia(FN) rate were compared between the two groups. Results There was no significant difference in the time to treatment failure between the two groups(P > 0. 05). The PSA response rate was 34. 6%(9 patients) in the 2-week docetaxel group and 42. 3%(11 patients) in the 3-week docetaxel group(P > 0. 05). The ≥ grade 3 leukopenia rate and the FN rate were lower in the 3-week group than in the 2-week group(P < 0. 05). Conclusion The treatment efficacy was comparable between the 2-week regimen of docetaxel and 3-week docetaxel regimen of for CRPC. The former is more tolerable and is worthy of clinical application.