甲福明改善对氯米芬抵抗的多囊卵巢综合征病人的排卵

目的 探讨氯米芬抵抗的多囊卵巢综合征病人胰岛素增敏剂甲福明对其激素及排卵的影响。方法 选择23例经氯米芬促排卵3个月（达150mg/d)无排卵的多囊卵巢综合征病人，应用甲福明每次500mg,3/d，连续用药1个月后，观察体重、血压、血糖、胰岛素、泌乳素、卵泡刺激素、卵泡刺激素、黄体生成素、雄烯二酮、睾酮、17－羟孕酮的变化，第二周期开始氯米芬促排卵，监测排卵及妊娠情况。结果 用药后空腹和糖负荷后的胰岛素水平、雄烯乙酮、睾酮、17－羟孕酮水平均明显下降，但血糖、体重、血压、泌乳素、卵泡刺激素和雄二醇均无明显变化，黄体生成素和黄体生成素／卵泡刺激素值有所减少，但无显著差异；23例中19例983.4%)有成熟卵泡发育，16例（69.6%)有排卵，2例（8.7%)妊娠。结论 甲福明能降低氯米芬抵抗多囊卵巢综合征病人的胰岛素、雄激素水平同时，改善氯米芬的促排卵。

Metformin Therapy Improve Ovullatory Rate in Clomiphene Citrate-resistant Women with Polycystic Ovary Syndrome

Objective To study the effect of metformin therapy on ovulation rates in clomiphene citrate(CC) resistant women with polycystic ovary syndrome(PCOS). Methods Twenty three women with clomiphene citrate resistant PCOS that had unovulation after taking CC for three monthes with most amount 100 mg/d were treat with metformin, 500 mg, tid, for one month. Glucose?Insulin?PRL?LH?FSH?E 2?A?T?17 OHP and body index?blood pressure and ovulation?pregnancy were valued. Results Metformin therapy resulted in a significant decrease in Insulin?A?T?17 OHP No significant change in glucose?blood pressure?PRL?FSH?E 2?LH?LH/FSH?BMI;Mature folicles were found in 19 cases in 23(83.4%), there were ovulationin 16cases(69 6%) and pregnancy in two cases(8.7%). Conclusion Metformin therapy not only decrease in insulin and androgens but also improve ovulation rates and pregnancy rates in clomiphene citrate(CC) resistant women with PCOS.