先兆早产孕妇血清IL-6和宫颈分泌物fFN测定的临床分析

目的：探讨血清白细胞介素-6（IL-6）、宫颈分泌物胎儿纤维连接蛋白（fFN）检测对预测早产的临床价值。方法：随机选择先兆早产孕妇38例作为先兆早产组，予以保胎治疗，根据保胎成功与否，又分为保胎成功组（26例）与保胎未成功组（12例）。检测保胎成功组、保胎未成功组治疗前后血清IL-6、宫颈分泌物fFN含量情况，并与正常妊娠组（36例）比较。结果：治疗前，先兆早产组（保胎未成功组、保胎成功组）血清IL-6、宫颈分泌物fFN明显高于正常妊娠体检组（均P〈0.01）。治疗后，保胎成功组血清IL-6、宫颈分泌物fFN明显低于保胎未成功组（均P〈0.01）；保胎成功组血清IL-6、宫颈分泌物fFN，与治疗前比较有明显降低（均P〈0.01）。结论：临床可以通过检测孕妇血清IL-6、宫颈分泌物fFN的含量来预测早产；同时，可以将上述指标的好转作为临床保胎治疗有效的指标。

Clinical Meanings of Determination of Serum IL-6 and Cervical Secretion Fetal Fibronectin Contents in Pregnant Women with Threatened Pre-term Labor

Objective To study clinical prediction value of determination of changes of serum IL - 6 and cervical secretion fetal fibronectin contents in pregnant women with threatened preterm labor. Methods Serum IL - 6 and cervical secretion fetal fibronectin （fFN） contents were determined with ELISA in 38 pregnant women with threatened preterm labor both before and after tocolytie treatment as well as 36 mormal pregnant women with gestation age 31.9 ± 2.3 weeks. Results Of the 38 treated cases, tocolytie therapy was successful in 26 cases and failed in 12 cases, Before teratment, the serum IL -6 and cervical secretion fFN contents in all these patients were significantly higher than those in normal pregnant women （P 〈 0.01 ）. After treatment, the levels of serum IL-6 and cervical secretion fFN were significantly lower in the treatment successful cases than those in the treatment failed cases （P 〈 0. 01）. In the treatment successful cases （n =26）, the serum IL-6 and cervical secretion fFN contents dropped significantly after the treatment （ vs before treatment, P 〈 0.01 ）. Conclusion Determination of serum IL - 6 and cervical secretion fFN contents might help to predict the development of pro - term labor and its outcom.