Attenuated adiposopathy in perivascular adipose tissue compared with subcutaneous human adipose tissue |
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Authors: | Christine R Mauro Godfrey Ilonzo Binh T Nguyen Peng Yu Ming Tao Ian Gao Michael A Seidman Louis L Nguyen C Keith Ozaki |
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Institution: | 1. Division of Vascular and Endovascular Surgery, Brigham and Women''s Hospital/Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA;2. Department of Pathology and Laboratory Medicine, Brigham and Women''s Hospital/Harvard Medical School, Boston, MA, USA |
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Abstract: | BackgroundWe hypothesized that human perivascular and subcutaneous adipose tissues hold distinct phenotypic signatures. We also evaluated the impact of clinical parameters on the adipose phenotype. Our overall goal is to understand the determinants of adipose biology so that this tissue can be manipulated therapeutically to lessen peripheral vascular disease.MethodsPerivascular and subcutaneous adipose tissues were collected from patients undergoing lower-extremity amputation (n = 27) and protein assayed for proinflammatory mediators (ie, interleukin 6, interleukin 8, leptin, tumor necrosis factor α, monocyte chemoattractant protein-1, and resistin), atheroprotective adiponectin, and the fibrinolysis inhibitor plasminogen activator inhibitor-1.ResultsLeptin (2.7-fold, P = .015), TNF-α (2.2-fold, P = .013), MCP-1 (1.5-fold, P = .047), and adiponectin (1.8-fold, P = .004) were more abundant in subcutaneous vs perivascular adipose tissue. Age positively correlated with perivascular adipose tissue PAI-1 expression (β = .64, P = .042), and hyperlipidemia negatively correlated with perivascular adiponectin (β = −1.18, P = .039).ConclusionsHuman perivascular and subcutaneous adipose tissues hold distinct phenotypic signatures. In amputation patients, the subcutaneous adipose tissue proinflammatory phenotype was relatively attenuated in perivascular adipose tissue. |
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Keywords: | Adipose Adipokine Perivascular |
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