Outcomes and prognostic factors in superficial spreading melanoma |
| |
| Authors: | Michael E Egger Lindsay O Stepp Glenda G Callender Amy R Quillo Robert CG Martin II Charles R Scoggins Arnold J Stromberg Kelly M McMasters |
| |
| Institution: | 1. Hiram C. Polk Jr MD Department of Surgery, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA;2. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA;3. Department of Statistics, University of Kentucky, Lexington, KY, USA |
| |
| Abstract: | BackgroundPrognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM).MethodsA single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used.ResultsA total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results.ConclusionsBT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM. |
| |
| Keywords: | Superficial spreading melanoma Sentinel lymph node biopsy melanoma Lymphovascular invasion Nonsentinel lymph node melanoma Melanoma histology Melanoma prognosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
