Biology of the estrogen receptor,GPR30, in triple negative breast cancer |
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Authors: | Jennifer Steiman Elizabeth A Peralta Somaja Louis Onsi Kamel |
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Institution: | 1. Department of Surgery, Southern Illinois University School of Medicine, Carbondale, IL, USA;2. Department of Breast Surgery, Sutter Pacific Medical Foundation, 3883 Airway Drive, Suite 203, Santa Rosa, CA 95403, USA |
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Abstract: | BackgroundTriple-negative (TN) breast cancer lacks a known signaling pathway amenable to targeted therapy. The authors hypothesized that the G protein–coupled receptor GPR30 may be present in TN breast cancer and serve a role for tumor growth.MethodsA retrospective pathology study and chart review were conducted. All patients aged ≤49 years from 2000 to 2008 were included (n = 24). Concurrent patients aged ≥50 years were randomly selected. Paraffin sections were stained for GPR30 and reviewed by a pathologist blinded to estrogen receptor and progesterone receptor status. Disease-free survival was analyzed versus age and receptor status. Means were compared using 2-sample t tests and proportions using chi-square analysis.ResultsTwenty-seven patients tested GPR30 positive and 21 GPR30 negative. Seventeen of 18 TN cancers tested positive for GPR30 (P < .0001). Recurrence at a mean follow-up of 36 months was 22.2% in the GPR30-positive group and 9.5% in the GPR30-negative group.ConclusionsGPR30 is prevalent in TN breast cancer and associated with young age and possibly recurrence. |
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Keywords: | G protein&ndash coupled receptor Triple-negative breast cancer Estrogen receptor Prognosis |
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