| P16、P21WAF1/CIP1、PCNA和cyclin E在脂溢性角化病中的表达及其意义 |
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| 引用本文： | 彭程,施岩,路麒,张莉.P16、P21WAF1/CIP1、PCNA和cyclin E在脂溢性角化病中的表达及其意义[J].中国麻风皮肤病杂志,2007,23(8):658-660. |
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| 作者姓名： | 彭程 施岩 路麒 张莉 |
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| 作者单位： | 山东大学山东省立医院皮肤性病科,济南,250021 |
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| 摘 要： | 目的：研究脂溢性角化病皮损组织中P16、P21^WAF1/CIP1、PCNA、cyclinE四种细胞周期素相关因子的表达及意义。方法：应用免疫组化PV法（改进的SP法），对50例脂溢性角化病病人和10例正常人皮肤进行P16、P21^WAF1/CIP1、PCNA、cyclinE四种细胞周期素相关因子的测定。结果：脂溢性角化病患者中这四种因子的表达阳性率分别为：78％、68％、70％、46％；而正常对照组的阳性率仅为：40％、30％、50％、10％。结论：P16、P21^WAF1/CIP1、PCNA、cyclinE四种细胞周期素相关因子在脂溢性角化病的发病中可能起重要作用。
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| 关 键 词： | 脂溢性角化 免疫组化 |
| 收稿时间： | 2006-10-23 |
| 修稿时间： | 2007-01-03 |
The expression and significance of P16, P21WAF1/CIP1 , PCNA and cyclin E in seborrheic keratosis |
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| Peng Cheng, Shi Yah, Lu Qi,et al..The expression and significance of P16, P21WAF1/CIP1 , PCNA and cyclin E in seborrheic keratosis[J].China Journal of Leprosy and Skin Diseases,2007,23(8):658-660. |
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| Authors: | Peng Cheng Shi Yah Lu Qi |
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| Affiliation: | Department of Dermatovenereology, Provincial Hospital Shandong University Shandong , Jinan, 250021 |
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| Abstract: | Objective:To determine the expression of P16,P21WAF1/CIP1,PCNA and cyclin E in seborrheic keratosis(SK)and to explore the significance of the expression.Methods:The expressions of P16,P21WAF1/CIP1,PCNA and cyclin E were detected by immunohistochemical method in 50 SK and 10 controls.Results:The positivity rates of P16,P21WAF1/CIP1,PCNA and cyclin E expressions in SK patients were 78%,68%,70% and 44% respectively,while the positivity rates of the expression in controls were 40%,30%,50% and 10% respectively.Conclusion:The expression of P16,P21WAF1/CIP1,PCNA and cyclin E may play a vital role in the pathogenesis of SK. |
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| Keywords: | P16 P21WAF1/CIP1 PCNA cyclin E |
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