| 小鼠鞘内注射吲哚美辛的镇痛作用与5-羟色胺的关系 |
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| 引用本文： | 朱忠宁,董六一,陈志武,宋必卫. 小鼠鞘内注射吲哚美辛的镇痛作用与5-羟色胺的关系[J]. 中国药理学通报, 2001, 17(2): 217-219 |
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| 作者姓名： | 朱忠宁 董六一 陈志武 宋必卫 |
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| 作者单位： | 1. 河北医科大学药学院,
2. 安徽医科大学药理学教研室, |
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| 摘 要： | 目的研究小鼠鞘内注射吲哚美辛的镇痛机制与５．羟色胺的关系。方法采用温浴法观察动物痛阈变化；荧光测定法测定脊髓组织５－羟色胺、５－羟吲哚乙酸含量变化。结果小鼠鞘内注射（ｉｔｈ）吲哚美辛 １．８ ｍｇ·ｋｇ－１具有明显的镇痛作用，其作用可被ｉｔｈ 噻庚啶拮抗，该剂量的吲哚美辛可升高脊髓组织内的５－羟吲哚乙酸水平，前列腺素对此无影响。结论 吲哚美辛可通过促进脊髓内 ５－ＨＴ的释放发挥脊髓镇痛作用，该作用与其前列腺素抑制作用无明显关系。
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| 关 键 词： | 吲哚美辛 非甾体抗炎药 脊髓镇痛 血清素 前列腺素 |
| 文章编号： | 1001-1978(2001)02-0217-03 |
The role of 5-HT inantinocieption produced by intrathecal indomethacin in mice |
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| ZHU Zhong-Ning,Dong Liu-yi,CHEN Zhi-Wu,SONG Bi-Wei. The role of 5-HT inantinocieption produced by intrathecal indomethacin in mice[J]. Chinese Pharmacological Bulletin, 2001, 17(2): 217-219 |
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| Authors: | ZHU Zhong-Ning Dong Liu-yi CHEN Zhi-Wu SONG Bi-Wei |
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| Abstract: | AIM To study the role of 5-HT in antinocieption produced by intrathecal indomethacin (Ind) in mice. METHOD The antinocieption of in domethacin was investigated on the tail immersion test in mice; the contents of 5-HT, 5-HAA were assayed with fluorescent method. RESULT Dose-de- pendent antinocieption was observed following intrathecal administration of Ind 1 .8 mg.kg- 1, the effect could be obliterated when the animals were pretreated with cyproheptadine. After intrathecal administration of Ind, the content of 5-HIAA in the spinal cord of mice was significantly increased, but PG had no effect. CONCLUSION The result imply that intrathecal indomethacin could produce antinocieption; this effect is mediated by 5-HT. PG does not participate in the action of 5-HT. |
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| Keywords: | indomethacin NSAIDs spinal cord serotonin prostaglandin |
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