| 1,6-二磷酸果糖对阿霉素所致大鼠心肌损伤的影响 |
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| 引用本文： | 李雅杰,刘宝刚,赵文然,孙辉.1,6-二磷酸果糖对阿霉素所致大鼠心肌损伤的影响[J].中国地方病学杂志,2003,22(4):305-307. |
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| 作者姓名： | 李雅杰 刘宝刚 赵文然 孙辉 |
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| 作者单位： | 1. 哈尔滨铁路中心医院,黑龙江,哈尔滨,150001
2. 哈尔滨医科大学,克山病研究所,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的研究1，6-二磷酸果糖(FDP)对阿霉素(ADM)导致大鼠心肌损伤的影响。方法采用wistar大鼠36只，随机分为ADM组、ADM FDP组及对照组。实验30d后进行心肌光镜病理形态学观察，测定血清及心肌超氧化物歧化酶(SOD)、肌酸激酶(CK)、乳酸脱氢酶(LDH)的活性及脂质过氧化物(LPO)的含量。结果光镜下ADM FDP组病理损害程度较ADM组轻；各组之间心肌及血清CK、LDH差异无统计学意义；和ADM组比较ADM FDP组血浆、心肌LPO含量显著降低，而SOD活性显著增加。结论FDP对ADM所致大鼠心肌损伤有保护作用。
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| 关 键 词： | 二磷酸果糖 阿霉素 大鼠 心肌损伤 FDP ADM 心肌细胞 |
| 文章编号： | 1000-4955(2003)02-0305-03 |
| 修稿时间： | 2003年3月31日 |
The effect of fructose-1, 6-diphosphate on the myocardial injury induced by adriamycin |
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| LI Ya-jie ,LIU Bao-gang ,ZHAO Wen-ran ,SUN Hui.The effect of fructose-1, 6-diphosphate on the myocardial injury induced by adriamycin[J].Chinese Jouranl of Endemiology,2003,22(4):305-307. |
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| Authors: | LI Ya-jie LIU Bao-gang ZHAO Wen-ran SUN Hui |
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| Affiliation: | LI Ya-jie 1,LIU Bao-gang 2,ZHAO Wen-ran 2,SUN Hui 2 |
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| Abstract: | Objective To study the effect of fructose-1, 6-diphosphate(FDP) on myocardial injury induced by adriamycin.Methods Thirty six Wistar rats were randomized into tre e groups: ADM group, ADM+FDP group, and control group. SOD, CK, LSH and LPO in t he sera and myocardium were detected and the histopathological study was perform ed.Results The extent of the myocardial injury in ADM+FDP group was not as significant as that in the ADM group. There was no significant difference in the activity of CK, LDH in sera and myocardium among all the group s. Compared with ADM group, the LPO of sera and mycardium in ADM+FDP group were higher and the activity of SOD was increased significantly.Conclusions FDP has protective effect on the myocardial injury induced by adriamycin. |
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| Keywords: | fructose-1 6-diphosphate adriamycin myocardial injury |
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