| 灯盏花素预处理对缺血再灌注心肌细胞凋亡的影响 |
| |
| 引用本文： | 龚明玉,刘永平,李芳,李燕. 灯盏花素预处理对缺血再灌注心肌细胞凋亡的影响[J]. 承德医学院学报, 2010, 27(1): 8-10. DOI: 10.3969/j.issn.1004-6879.2010.01.004 |
| |
| 作者姓名： | 龚明玉 刘永平 李芳 李燕 |
| |
| 作者单位： | 承德医学院生物化学教研室,河北承德,067000;承德医学院2006级临床本科 |
| |
| 摘 要： | 目的：观察灯盏花素预处理对大鼠缺血再灌注心肌细胞凋亡的影响。方法：40只SD大鼠随机分为假手术组、模型组、灯盏花素预处理Ⅰ组和Ⅱ组。灯盏花素预处理组大鼠于术前1周腹腔注射不同剂量的灯盏花素（25、50mg／kg／d）；采用结扎大鼠左冠状动脉前室间支的方法制备心肌缺血再灌注模型，结扎30min，再灌注2h；采用Annexin V／PI双染，流式细胞仪检测心肌细胞的凋亡情况。结果：灯盏花素预处理可明显降低缺血再灌注大鼠心肌细胞的凋亡率（P〈0．05，P〈0．01）。结论：灯盏花素预处理可抑制心肌细胞凋亡，对缺血再灌注心肌细胞具有保护作用。
|
| 关 键 词： | 灯盏花素 细胞凋亡 心肌细胞 缺血再灌注 磷脂酰丝氨酸 |
EFFECTS OF BREVISCAPINE PRETREATMENT ON MYOCCARDIAL CELLS APOPTOSIS OF CARDIAC ISCHEMIA/REPERFUSION RATS |
| |
| GONG Ming-yu,LIU Yong-ping,LI Fang,et al. EFFECTS OF BREVISCAPINE PRETREATMENT ON MYOCCARDIAL CELLS APOPTOSIS OF CARDIAC ISCHEMIA/REPERFUSION RATS[J]. Journal of Chengde Medical College, 2010, 27(1): 8-10. DOI: 10.3969/j.issn.1004-6879.2010.01.004 |
| |
| Authors: | GONG Ming-yu LIU Yong-ping LI Fang et al |
| |
| Affiliation: | Department of Biochemistry;Chengde Medical College;Hebei Chengde 067000;China |
| |
| Abstract: | Objective:To investigate protective effects of breviscapine pretreatment on myocardial cells apoptosis of ischemia/reperfusion injury rats.Methods:40 SD rats were divided into sham operation group,model group and 2 breviscapine pretreatment groups at random (n=10).The rats in breviscapine pretreatment groups were intraperitoneally injected 25 mg/kg/d and 50 mg/kg/d breviscapine respectively 1 week prior to ischemia/reperfusion;while the rats in other two groups were given NS instead.Myocardial ischemia/repe... |
| |
| Keywords: | Breviscapine Apoptosis Myocardial Cell Ischemia/reperfusion Phosphatidylserine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
