Eosinophilia associated with proliferation of CD3+4−8−αβ+ T cells with chromosome 16 anomalies |
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| Authors: | Kiyoshi,Kitano ,Naoaki,Ichikawa ,Bilkis,Mahbub ,Mayumi,Ueno ,Toshiro,Ito ,Sigetaka,Shimodaira ,Hiroshi,Kodaira ,Fumihiro,Ishida ,Hikaru,Kobayashi ,Hiroshi,Saito ,Yoshio,Okubo ,Hideo,Enokihara & Kendo,Kiyosawa |
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| Affiliation: | The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto,;Internal Medicine, Nagano Red Cross Hospital, Nagano,;The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, and;;The Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi-ken, Japan |
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| Abstract: | We describe a patient with eosinophilia and an abnormal CD3+4−8−αβ+ T-cell population. Chromosomal analysis of sorted CD3+4−8− cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD3+4−8− cells was higher than that from CD3+4+/8+ cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD3+4−8− cells might cause eosinophilia. |
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| Keywords: | eosinophilia double-negative T cells IL-5 GM-CSF chromosome 16 anomaly |
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