Eosinophilia associated with proliferation of CD3+4−8−αβ+ T cells with chromosome 16 anomalies期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Eosinophilia associated with proliferation of CD3⁺4⁻8⁻αβ⁺ T cells with chromosome 16 anomalies

Authors:	Kiyoshi Kitano Naoaki Ichikawa Bilkis Mahbub Mayumi Ueno Toshiro Ito Sigetaka Shimodaira Hiroshi Kodaira Fumihiro Ishida Hikaru Kobayashi Hiroshi Saito Yoshio Okubo Hideo Enokihara & Kendo Kiyosawa

Institution:	The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto,;Internal Medicine, Nagano Red Cross Hospital, Nagano,;The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, and;;The Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi-ken, Japan

Abstract:	We describe a patient with eosinophilia and an abnormal CD3⁺4⁻8⁻αβ⁺ T-cell population. Chromosomal analysis of sorted CD3⁺4⁻8⁻ cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD3⁺4⁻8⁻ cells was higher than that from CD3⁺4⁺/8⁺ cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD3⁺4⁻8⁻ cells might cause eosinophilia.

Keywords:	eosinophilia double-negative T cells IL-5 GM-CSF chromosome 16 anomaly