| New development in risk assessment of genotoxic carcinogens in foods |
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| 摘 要： | Theno observed effectlevel(NOEL)inastudyofcarcinogenicityforcompoundsthatarebothgenotoxicand carcinogenicrepresentsthelimitofdetectioninthatbioassay,ratherthananestimateofapossiblethreshold.Therefore,forthosegenotoxicandcarcinogeniccontaminants(e.g.acrylamides,PAHs,etc.)infoodsitisnot possibletodevelophealth basedguidancevalues(e.g.ADIorPTWI)usingthetraditionalNOELandsafety/un certaintyfactors.Usually,theALARAprincipleisused,i.e.intakesshouldbereducedtoaslowasreasonably achievable.Suc…
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New development in risk assessment of genotoxic carcinogens in foods |
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| Abstract: | The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible threshold. Therefore, for those genotoxic and carcinogenic contaminants (e.g. acrylamides, PAHs, etc.) in foods it is not possible to develop health-based guidance values (e.g. ADI or PTWI) using the traditional NOEL and safety/uncertainty factors. |
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