Sequence Analysis Demonstrates that VP6, NSP1 and NSP4 Genes of Indian Neonatal Rotavirus Strain 116E are of Human Origin |
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| Authors: | Nigel A Cunliffe Bimal K Das Madhumati Ramachandran Maharaj K Bhan Roger I Glass Jon R Gentsch |
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| Institution: | (1) Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Health and Human Services, Viral Gastroenteritis Section, Atlanta, Georgia;(2) Department of Medical Microbiology and Genito-urinary Medicine and Wellcome Trust Liverpool Centre for Clinical Tropical Medicine, University of Liverpool, Liverpool, UK;(3) Departments of Pediatrics and Microbiology, All India Institute of Medical Sciences, New Delhi, India |
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| Abstract: | We have sequenced the genes encoding the inner capsid protein VP6 and the nonstructural proteins NSP1 and NSP4 of the Indian
neonatal serotype P811]G9 human/bovine reassortant candidate vaccine rotavirus strain 116E. These three genes share a high
degree of sequence and deduced amino acid homology with human prototype strain Wa. Our results confirm and extend those of
previous RNA-RNA hybridization studies which suggested that these genes are of human origin, and will facilitate examination
of the host immune response to 116E induced by natural infection and vaccination.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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| Keywords: | rotavirus neonate 116E nucleotide sequence vaccine |
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