间接性颞下颌关节损伤后局部骨形成蛋白的表达及其意义

目的观察间接性颞下颌关节（TMJ）损伤后局部骨形成蛋白（BMP）的表达，探讨关节损伤与颞下颌关节骨关节病（TMJOA）的关系。方法用自制撞击装置间接造成羊右侧关节损伤，左侧关节为对照。伤后2h、一、三、六月取材，通过免疫组化的方法，利用BMP单克隆抗体观察伤后TMJ组织中BMP的表达。结果TMJ伤后早期BMP表达增强，后期BMP表达明显减弱。结论TMJ损伤导致TMJOA的机理是由于损伤破坏了髁突表面屏障。破坏和抑制了软骨的增殖能力，导致TMJOA。

Expression of BMP in temporomandibular joint following indirect trauma

:Objective To study teh expression of bone morphogenitic protein (BMP) in temporomandibular joint(TMJ). Methods Trauma to the TMJ was achieved under an impact to the right mandibular angle of 20 goats with self- made device, the left TMJ was used as a control. The animals were killed after2h, lmonth, 3month and 6month. BMPexpression was studied with immunohistochemical technique. Results increased BMP expression was observed in TMJlmonth after trauma; decreased BMP expression was observed in TMJ 3month and 6month after trauma. Conclusion Themechanism of the experimental process is probably that trauma to the TMJ damaged its natural barrier, the proliferating ability of the cartilage cell was destroyed. then caused TMJ osteoarthrosis (TMJOA ).