Influence of magnesium ion on human ventricular defibrillation after aortocoronary bypass surgery |
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| Authors: | B R Hecker C L Lake I L Kron R M Mentzer I K Crosby S P Nolan R S Crampton |
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| Affiliation: | 1. Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada;2. ICES, Toronto, Ontario, Canada;3. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada;4. Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario, Canada;1. State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China;2. Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China;3. International Joint Research Center for Sustainable Urban Water System, Tongji University, Shanghai, 200092, PR China;4. College of Environmental Science and Engineering, Beijing Key Laboratory for Source Control Technology of Water Pollution, Beijing Forestry University, Beijing, 100083, PR China;5. Key Laboratory of Yangtze Water Environment of Ministry of the State Education, Tongji University, Shanghai, 200092, PR China;1. Department of Clinical Medicine, University Campus Bio-Medico, Rome, Italy;2. Department of Cardiology, II School of Medicine, University La Sapienza, Ospedale Sant’Andrea, Rome, Italy;3. Virginia Commonwealth University-VCU Pauley Heart Center, Richmond, VA, USA;4. Department of Physiology and Pathology, University of Trieste, Trieste, Italy;1. Department of Management, College of Business and Economics, Lehigh University, 621 Taylor Street, Bethlehem, PA 18015, USA;2. Department of Management, Robert J. Trulaske, Sr. College of Business, University of Missouri, 517 Cornell Hall, Columbia, MO 65211, USA |
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| Abstract: | The administration of magnesium ion (Mg++) has been reported to defibrillate the ventricles and to decrease the incidence of arrhythmias after cardiopulmonary bypass. In a prospective study of 76 randomly selected patients undergoing coronary artery bypass grafting, patients received either no Mg++, 0.25 mEq/kg of Mg++ during cardiopulmonary bypass with the aorta clamped, or 0.375 mEq/kg of Mg++ before cardiopulmonary bypass. Spontaneous resumption of a cardiac rhythm or spontaneous defibrillation during reperfusion was not significantly affected by Mg++ administration. However, the number of shocks to initial and to sustained defibrillation and the energy required for the last direct-current shock was greatest in patients who received Mg++ before bypass and in those whose plasma Mg++ was greater than 2.26 mg/dl. Thus, the administration of Mg++ may have adverse effects on the heart if intraoperative plasma Mg++ exceeds 2.26 mg/dl. |
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