| 牦牛骨形态发生蛋白及其与陶瓷化异种骨复合修复兔桡骨缺损的实验研究 |
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| 引用本文： | 刘春选,冯守诚,李蕴麟,王翠芳,孙正义. 牦牛骨形态发生蛋白及其与陶瓷化异种骨复合修复兔桡骨缺损的实验研究[J]. 兰州大学学报(医学版), 1993, 0(1) |
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| 作者姓名： | 刘春选 冯守诚 李蕴麟 王翠芳 孙正义 |
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| 作者单位： | 兰州医学院骨科研究所，兰州医学院骨科研究所，兰州医学院骨科研究所，兰州医学院骨科研究所，兰州医学院骨科研究所 |
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| 摘 要： | 本实验采用yBMP和yBMP/CBB材料,修复1.5cm长的兔桡骨缺损。分yBMP和yBMP/CBB二个实验组。材料植入20天,缺损区均分别生成多量软骨及交织骨。40天,大量交织骨生成,其间出现骨髓组织。60天,板层骨增多。80天,板层骨进一步成熟,骨缺损修复。与之对照,空白组各期仅见两端形成交织骨。这表明:yBMP及yBMP/CBB对骨缺损的修复作用非常显著。
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| 关 键 词： | 骨形态发生蛋白 骨缺损 陶瓷化异种骨 |
Experimental Studies on the Repairing of Radius Defects with Yak Bone Morphogenetic Protein(yBMP)and It''''s Composite in Rabbits |
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| Liu Chunxuan. Experimental Studies on the Repairing of Radius Defects with Yak Bone Morphogenetic Protein(yBMP)and It''''s Composite in Rabbits[J]. Journal of Lanzhou University (Medical Sciences), 1993, 0(1) |
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| Authors: | Liu Chunxuan |
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| Affiliation: | The Institute of Orthopaedics of Lanzhou Medical College |
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| Abstract: | Ceramic bovine bone (CBB) was employed as a nonimmunogenic biodegradable delivery system for yak bone morphogenetic protein (yBMP). yBMP and yBMP/CBB composite were implanted in rabbits with radius defects of a critical size of 1.5cm that would otherwise remain unhealed in the lifetime of the individual. Following implantation of them, cartilage and a little woven bone growth was induced in the pores or/and on the surface of the implants on the 20th day,a large of woven bone on the 40th day, lamellar bone and marrow on the 60th day, respectively. The CBB was broken and phagacytosed in yBMP/CBB group after the 20th day. Lamellar bone further matures on the 80th day. In contrast to above,no woven and lamellar bone in centre of defects was grown to control on the 80th day. The results of this study indicated that yBMP and yBMP/CBB composite possess a superior ability of osteogenesis. |
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| Keywords: | BMP Bone defects Yak |
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