围绝经期抑郁与女性激素水平的相关性

目的探讨围绝经期抑郁患者女性激素水平与抑郁的关系。方法选择围绝经期抑郁患者100例设为抑郁组,围绝经期无抑郁健康者100例设为对照组;采用汉密顿抑郁量表(HAMD,24项)评定临床抑郁症状,采用化学发光法检测血清雌二醇(E2)、孕酮(P)水平。结果抑郁组E2检测结果与对照组比较差异无统计学意义(18.28±11.65 vs 21.31±10.97, P>0.05);P检测结果与对照组比较差异有统计学意义(0.97±0.25 vs 0.48±0.26, P<0.05);E2/P比值与对照组比较差异有统计学意义(21.30±11.97 vs 37.71±15.27, P<0.01); HAMD评定结果与P呈正相关,与E2/P比值呈负相关。结论围绝经期抑郁者内源性激素水平与健康者不同,雌激素和孕激素调节功能的紊乱可能是围绝经期抑郁发病机制之一。

Female sex hormone levels and peri-menopause depression disorder

To investigate the correlation between peri menopause depression disorder and female sex hormone levels. Methods100 peri menopausal women with depression disorder were assessed and 100 peri menopause ones without depression disorder served as controls. The Hamilton Depression Scale was used to evaluate their depressive symptoms. Chemiluminescence Determination was adopted to determine the serum E2 and P levels. Result① Level of E2 had no significant difference between the two groups (18.28±11.65 vs 21.31±10.97,  P>0.05). ②The depression group exhibited a significant increase in P level compared with the controls (0.97±0.25 vs 0.48±0.26, P<0.05). Moreover, the ratio of E2/P was statistically decreased in the depression group in contrast to the control group (21.30±11.97 vs 37.71±15.27, P<0.01). ③A positive correlation was found between P and HAMD, whereas a negative correlation between E2/P and HAMD was demonstrated. ConclusionDysfunction of E2 and P secretion might be involved in the mechanism of peri menopausal depression disorder.