Components of the metabolic syndrome and risk of prostate cancer: the HUNT 2 cohort, Norway |
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Authors: | Richard M Martin Lars Vatten David Gunnell Pål Romundstad Tom I L Nilsen |
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Institution: | (1) Department of Social Medicine, University of Bristol, Bristol, BS8 2PR, UK;(2) Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway;(3) International Agency for Research on Cancer, Lyon, France;(4) Human Movement Science Program, Norwegian University of Science and Technology, Trondheim, Norway |
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Abstract: | Background The metabolic syndrome has been suggested as a unifying link between a “western” lifestyle and an increased prostate cancer risk. Methods We assessed the associations of components of the metabolic syndrome with prostate cancer in a prospective cohort based on 29,364 Norwegian men followed up for prostate cancer incidence and mortality from 1995–1997 to the end of 2005 in the second Nord Trøndelag Health Study (HUNT 2). Results During a mean 9.3 years follow-up, 687 incident prostate cancers were diagnosed, and 110 men died from prostate cancer. There was little evidence that baseline BMI, waist circumference, waist–hip ratio, total or HDL-cholesterol, triglycerides, presence of the metabolic syndrome, diabetes, antihypertensive use, or cardiovascular disease were associated with incident or fatal prostate cancer. There was weak evidence that raised blood pressure was associated with an increased risk: for each SD (12 mm) increase in diastolic blood pressure, there was an 8% (95% CI = 1–17%; p = 0.04) increased risk of incident prostate cancer. Conclusions We found little evidence to support the hypothesis that the metabolic syndrome or its components explains higher prostate cancer mortality rates in countries with a “western” diet and lifestyle. The positive association of blood pressure with prostate cancer warrants further investigation. |
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Keywords: | Prostate cancer Metabolic syndrome Blood pressure Waist circumference Waist:hip ratio Body mass index Obesity Total cholesterol High density lipoprotein cholesterol Triglycerides |
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