| 三氟乙酰伯氨喹合成产品高效毛细管电泳分析与高效液相色谱分析的比较研究 |
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| 引用本文： | 范国荣,林梅,张正行,安登魁,陈伟,朱兰.三氟乙酰伯氨喹合成产品高效毛细管电泳分析与高效液相色谱分析的比较研究[J].中国药科大学学报,1996(3):49-51. |
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| 作者姓名： | 范国荣 林梅 张正行 安登魁 陈伟 朱兰 |
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| 作者单位： | 中国药科大学药物分析研究室 |
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| 摘 要： | 建立了适合抗疟新药三氟乙酰伯氨喹合成产品分离分析的高效毛细管电泳与高效液相色谱方法。通过对两种方法之间分离效能、线性范围、定量重现性、方法回收率、最低检测限及分离分析时间的比较研究，明确了在药物生产质量控制过程中，高效毛细管电泳技术将是高效液相色谱技术理想的补充手段。
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| 关 键 词： | 三氟乙酰伯氨喹 高效毛细管电泳 高效液相色谱 |
Comparative Study of HPCE and HPLC for the Analysis of Synthetic Product, Trifluoroacetyl Primaquine |
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| Fan Guorong,Lin Mei,Zhang Zhengxing,An Dengkui,Chen Wei,Zhu Lan.Comparative Study of HPCE and HPLC for the Analysis of Synthetic Product, Trifluoroacetyl Primaquine[J].Journal of China Pharmaceutical University,1996(3):49-51. |
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| Authors: | Fan Guorong Lin Mei Zhang Zhengxing An Dengkui Chen Wei Zhu Lan |
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| Institution: | Fan Guorong,Lin Mei,Zhang Zhengxing,An Dengkui,Chen Wei,Zhu Lan Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | The separate and analytical methods were established for the analysis of synthetic product, the new anti malarial drug trifluoroacetyl primaquine(M 8506 ) by high performance capillary electrophoresis(HPCE) and high performance liquid chromatography(HPLC). The two methods were then compared in terms of separation efficiency, linearity, precision, recovery, detection limit and analytical time. The conclusion was that HPCE should be an ideal alternative method for HPLC during the quality control of pharmaceutical production process. |
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| Keywords: | Trifluoroacetyl primaquine HPCE HPLC |
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