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Psychometric properties of the apathy evaluation scale in patients with Parkinson's disease |
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| Authors: | Ulrike Lueken Ricarda Evens Monika Balzer‐Geldsetzer Simon Baudrexel Richard Dodel Susanne Gräber‐Sultan Rüdiger Hilker‐Roggendorf Elke Kalbe Oliver Kaut Brit Mollenhauer Kathrin Reetz Eva Schäffer Nele Schmidt Jörg B. Schulz Annika Spottke Karsten Witt Katharina Linse Alexander Storch Oliver Riedel |
| Affiliation: | 1. Department of Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Würzburg, Würzburg, Germany;2. Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universit?t Dresden, Dresden, Germany;3. Department of Neurology, Phillips University Marburg, Marburg, Germany;4. Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany;5. Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University Tübingen, Tübingen, Germany;6. Department of Medical Psychology: Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), University Hospital Cologne, Cologne, Germany;7. Department of Neurology, University Hospital Bonn, and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany;8. Paracelsus‐Elena‐Klinik, Kassel, Germany;9. Department of Neurology, RWTH Aachen University, Aachen, (Germany);10. JARA – Translational Brain Medicine, Jülich and Aachen, Aachen, Germany;11. Institute of Neuroscience and Medicine (INM 11), Research Center Jülich GmbH, Jülich, Germany;12. Department of Neurology, Christian Albrechts University, Kiel, Germany;13. Division of Neurodegenerative Diseases, Department of Neurology, Technische Universit?t Dresden, Dresden, Germany;14. Department of Neurology, University of Rostock, Rostock, Germany;15. Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology – BIPS GmbH, Bremen, Germany |
| Abstract: | Parkinson's disease (PD) frequently entails non‐motor symptoms, worsening the course of the disease. Apathy is one of the core neuropsychiatric symptoms that has been investigated in recent years; research is however hampered by the limited availability of well‐evaluated apathy scales for these patients. We evaluated the psychometric properties of the Apathy Evaluation Scale (AES) in a sample of PD patients. Psychometric properties, convergent and discriminant validity and sensitivity/specificity were evaluated in patients with (n = 582) or without dementia/depression (n = 339). Internal consistency was high in the entire sample as well as in patients without dementia/depression. Correlations were moderate for convergent validity (UPDRS I item 4: motivation). While apathy could be differentiated from cognitive decline, it was related to depression (Geriatric Depression Scale, GDS‐15). The overall classification accuracy based on the UPDRS I item 4 was comparable for AES and GDS scores. The AES exhibits good psychometric properties in PD patients with and without dementia and/or depression. Commonly used screenings on the presence of apathy had low detection rates compared to the AES and reflected both apathetic and depressive symptoms. Psychometric evaluation of available instruments will support further research on the clinical relevance of apathy for disease progression and treatment approaches in PD patients. |
| Keywords: | apathy depression Parkinson's disease psychometrics validity |