Applications of Powder X-Ray Diffraction in Small Molecule Pharmaceuticals: Achievements and Aspirations |
| |
Authors: | Naveen K Thakral Roger L Zanon Ron C Kelly Seema Thakral |
| |
Institution: | 1. Upsher-Smith Laboratories LLC, Maple Grove, Minnesota 55369;2. Amgen Inc., Thousand Oaks, California 91320;3. Characterization Facility, University of Minnesota, Minneapolis, Minnesota 55455 |
| |
Abstract: | Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry, powder X-ray diffraction has found diverse applications in the field of pharmaceutical sciences. This review summarizes significant achievements of the technique during various stages of dosage form development. Improved understanding of the principle involved and development of automated hardware and reliable software have led to increased instrumental sensitivity and improved data analysis. These advances continue to expand the applications of powder X-ray diffraction to emerging research fields such as amorphous systems, mechanistic understanding of phase transformations, and “Quality by Design” in formulation development. |
| |
Keywords: | powder X-ray diffraction polymorphism phase transformations formulations physical characterization |
本文献已被 ScienceDirect 等数据库收录! |
|