| 小剂量左旋精氨酸在实验性急性胰腺炎中的作用 |
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| 引用本文： | 孙晓刚,闫军,李燕书. 小剂量左旋精氨酸在实验性急性胰腺炎中的作用[J]. 山西医科大学学报, 2007, 38(6): 516-518 |
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| 作者姓名： | 孙晓刚 闫军 李燕书 |
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| 作者单位： | 山西医科大学第一临床医学院普外科,太原,030001 |
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| 摘 要： | 目的 探讨小剂量左旋精氨酸（L-Arg）在实验性大鼠急性胰腺炎中的治疗效果。方法 观察小剂量L-Arg（100mg/kg）治疗急性胰腺炎（AP）大鼠后血清淀粉酶、胰腺组织中的一氧化氮（NO）浓度、诱导型一氧化氮合酶（iNOS）含量以及胰腺组织的病理变化。结果 治疗组血清、胰组织NO浓度显著升高，iNOS的表达和胰腺组织病理评分显著降低。结论 小剂量左旋精氨酸（L-Arg）应用可对胰腺起保护作用。
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| 关 键 词： | 胰腺炎 左旋精氨酸 一氧化氮 |
| 文章编号： | 1007-6611（2007）06-0516-03 |
| 修稿时间： | 2007-01-29 |
Effect of low dose of L-arginine in treatment of acute pancreatitis in rats |
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| SUN Xiao-gang,YAN Jun,LI Yan-shu. Effect of low dose of L-arginine in treatment of acute pancreatitis in rats[J]. Journal of Shanxi Medical University, 2007, 38(6): 516-518 |
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| Authors: | SUN Xiao-gang YAN Jun LI Yan-shu |
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| Affiliation: | Dept of Surgery,First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To investigate the effect of low dose of L-arginine on acute pancreatitis in Spriague-Dawleg(SD)rats.MethodsAfter given low-dose of L-arginine(100 mg/kg),the serum amylase,the levels of nitric oxide and iNOS in plasma and pancreatric tissues,and the pathological changes of pancreatric tissues were detected and observed in SD rats of acute pancreatitis.ResultsIn treated group,the level of nitric oxide in plasma and pancreatric tissues significantly increased,while iNOS expression and pathological changes significantly decreased.ConclusionThe low-dose of L-arginine could protect the pancreas. |
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| Keywords: | pancreatitis L-arginine NO |
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