林格氏液关节腔灌洗与欣维可腔内注射治疗膝关节骨性关节炎的对比

目的〓〖HTK〗观察和对比分析林格氏液关节腔灌洗与欣维可(玻璃酸钠)腔内注射对膝关节骨关节炎的临床疗效。〖HTW〗方法〓〖HTK〗将58例单膝骨关节炎患者随机分成单纯林格氏液关节腔灌洗组、单纯欣维可关节腔内注射组和关节腔灌洗+欣维可腔内注射组。采用WOMAC量表分别在治疗前、治疗后1、8、12、24和52周进行治疗效果评定。所有治疗在同一医院由同一组医生完成，采用单盲（病员侧）方法。 借助Stata软件，采用混合模型的方法对重复测量的资料进行分析。〖HTW〗结果〓〖HTK〗① 单纯关节腔灌洗、单纯欣维可关节腔内注射和关节腔灌洗+欣维可腔内注射均在治疗后8、12和24周有明显的临床治疗效果（P＜0.05)，后两组在52周仍有明显的临床治疗效果（P＜0.05)；② 单纯欣维可关节腔内注射和关节腔灌洗+欣维可腔内注射的临床治疗效果优于单纯关节腔灌洗(P＜0.05)；③ 关节腔灌洗+欣维可腔内注射治疗后1周，在减轻疼痛方面优于单纯欣维可关节腔内注射(P＜0.05)，在其他时段上无明显治疗差异（P＞0.05）。〖HTW〗结论〓〖HTK〗单纯林格氏液关节腔灌洗及单纯欣维可关节腔内注射治疗膝关节骨关节炎均有明显的临床治疗效果，二者联合应用并不能明显增加疗效。单纯欣维可关节腔内注射治疗骨性关节炎效果佳较单纯林格氏液关节腔灌洗明显，且持续时间长，操作简单。

Ringer's solution and Synvisc in treatment of knee osteoarthritis: a contrast study

Objective〓〖WTBZ〗To explore the effects of Ringer′s solution and Synvisc in treatment of knee osteoarthritis(OA). 〖WTHZ〗Methods〓〖WTBZ〗A total 58 outpatients with knee osteoarthritis were randomly divided into three groups. Group A accepted simple intra-articular irrigation of Ringer′s solution, group B accepted simple Synvisc injection and group C accepted both intra-articular irrigation of Ringer′s solution and Synvisc injection. Westem Ontario and McMaster University Osteoarthritis Index (WOMAC) pain score were used to assess the effects before treatment andJP2]1, 8, 12, 24 and 52 weeks after treatment. All treatments were finished by the sam doctor group in the Qingdao Municipal Hospital by a patient-blinded method. All analyses were performed by the Stata software. 〖WTHZ〗Results〓〖WTBZ〗All three groups had the WOMAC pain scores significantlyJP2] improved at 8, 12 and 24 weeks(P＜0.05), and groups B and C still had significant effects at 52 weeks (P＜0.05). Groups B and C were superior to group A in clinical efficacy(P＜0.05), and group C was superior to group B in pain relief at 1-week term(P＜0.05). 〖JP2〗〖WTHZ〗Conclusions〓〖WTBZ〗Either Ringer′s solution or Synvisc injection can significantly improve the WOMAC pain scores for knee osteoarthritis, and Synvisc injection is superior to Ringer′s solution in pain-relief, duration and operative briefness， but there are no folded effects when they are used in combination.