经皮急性主动脉瓣关闭不全犬模型的建立

目的 探讨通过经外周血管经导管微创的方法建立大动物主动脉瓣膜反流模型的可行性和有效性。方法 选择健康犬10只,穿刺右侧股动脉,经鞘管送入冠状动脉介入导丝的硬头端,穿刺主动脉瓣叶并送入球囊扩张瓣叶穿刺口达到损坏瓣膜,建立主动脉瓣关闭不全的模型。手术后即刻通过主动脉瓣上造影及经胸超声确定主动脉瓣反流程度。结果 10只实验犬即时主动脉瓣反流模型均成功建立。其中2只因主动脉瓣反流量过大致急性左心衰当场死亡。存活8只犬经术后主动脉瓣上造影及超声检查证实其中6只为中量主动脉瓣反流,2只为少量反流。术后存活超过1个月。结论 经外周血管经导管微创的方法建立大动物主动脉瓣膜反流模型可行。

Establishment of a canine model of a percutaneous acute aortic valve regurgitation

Objective To explore the feasibility and effectiveness of establishing an aortic valve regurgitation canine model by minimally invasive peripheral vascular catheter method. Methods A total of 10 healthy canines were selected in this study. An aortic insufficiency animal model was established by percutaneous femoral artery puncture and aortic dilatation. Aortic angiography and transthoracic echocardiography were used to evaluate aortic valve regurgitation immediately after operation. Results Aortic valve regurgitation animal models were successfully established in all the 10 canines. Two canines died of acute left ventricular failure due to the large aortic regurgitation after the operation. Six surviving canines had moderate aortic regurgitation and two had slight aortic regurgitation; they survived for more than 1 month. Conclusion It is feasible to establish an aortic regurgitation canine model by minimally invasive peripheral vascular catheter method.