| 中药肠吸收的研究进展 |
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| 引用本文： | 吴涛,郑娟,张程亮,刘东. 中药肠吸收的研究进展[J]. 药品评价, 2013, 0(6): 30-35 |
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| 作者姓名： | 吴涛 郑娟 张程亮 刘东 |
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| 作者单位： | 吴涛 (华中科技大学同济医学院附属同济医院药学部,武汉430033)；郑娟 (湖北省中山医院药学部,湖北武汉430033)； 张程亮 (华中科技大学同济医学院附属同济医院药学部,武汉430033)；刘东* (华中科技大学同济医学院附属同济医院药学部,武汉430033)； |
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| 基金项目： | 中央高校基本科研业务费资助,项目名称：基于Caco-2细胞CES表达缺陷的改良及用于酯类前药体外吸收评价的的研究;编号：HUST：2012QNl82 |
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| 摘 要： | 本文对今年来国内外研究中药肠吸收的文献进行了检索和分析，介绍了目前常用的研究中药肠吸收的方法和模型．并对中药有效单体成分的肠吸收、中药单味药和复方的肠吸收以及影响中药肠吸收的因素进行了综述，在此基础上介绍了促进中药肠吸收的策略。旨在为提高中药的口服生物利用度、改进中药剂型、发现中药新药和临床合理使用中药提供参考。
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| 关 键 词： | 中药 药动学 肠吸收 药物转运体 |
Advances in studies on intestinal absorption of Traditional Chinese Medicine |
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| WU Tao,ZHENG Juan,ZHANG Cheng-liang,LIU Dong. Advances in studies on intestinal absorption of Traditional Chinese Medicine[J]. Drug Evaluation, 2013, 0(6): 30-35 |
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| Authors: | WU Tao ZHENG Juan ZHANG Cheng-liang LIU Dong |
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| Affiliation: | 1. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430033, China; 2. Department of Pharmacy, Hubei Zhongshan Hospital, Wuhan 430033, China) |
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| Abstract: | This review analyzed domestic and foreign literatures on intestinal absorption, introduced the current methods and models commonly used in traditional Chinese medicine researches focused on intestinal absorption, and their efficacy and impact on monomer components intestinal absorption of single herbs and compound Chinese medicine, in order to promote the efficacy of intestinal absorption of traditional Chinese medicine, provide a reference for improving the oral bioavailability of Chinese medicine, improve Chinese medicine formulations, new Chinese medicine and clinical rational use of traditional Chinese medicine. |
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| Keywords: | Traditional Chinese Medicine Pharmacokinetics Intestinal Absorption Drug Transporter |
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