| 替诺福韦酯初始治疗应答不佳的相关因素分析:病例报道及文献复习 |
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| 引用本文： | 曹敏玲,池晓玲,蒋俊民,唐永煌,周粤湘.替诺福韦酯初始治疗应答不佳的相关因素分析:病例报道及文献复习[J].胃肠病学和肝病学杂志,2019(8):904-907. |
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| 作者姓名： | 曹敏玲 池晓玲 蒋俊民 唐永煌 周粤湘 |
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| 作者单位： | 广东省中医院肝病科;广州华侨医院;广州中医药大学 |
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| 摘 要： | 替诺福韦酯(TDF)是治疗慢性乙型肝炎(chronic hepatitis B, CHB)的一线核苷类似物。目前国内暂未出现TDF耐药案例。本文介绍1例40岁的HBeAg阴性CHB男性患者接受TDF 300 mg/d治疗,初始HBV定量基线水平较低,在治疗后6个月无法检测。然而,在TDF治疗12个月后出现反弹。我们试图找到与病毒学突破相关的突变位点,最终双中心耐药基因分析结果显示未找到突变位点。本文在最后也对患者TDF应答不佳的情况进行确认,并对造成TDF应答不佳的几种因素进行分析,以供业界参考。
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| 关 键 词： | 慢性乙型肝炎 替诺福韦酯 耐药 位点 应答不佳 影响因素 |
Relevant factors for poor response to initial treatment with Tenofovir disoproxil fumarate: one case report and literature review |
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| CAO Minling,CHI Xiaoling,JIANG Junmin,TANG Yonghuang,ZHOU Yuexiang.Relevant factors for poor response to initial treatment with Tenofovir disoproxil fumarate: one case report and literature review[J].Chinese Journal of Gastroenterology and Hepatology,2019(8):904-907. |
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| Authors: | CAO Minling CHI Xiaoling JIANG Junmin TANG Yonghuang ZHOU Yuexiang |
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| Institution: | (Department of Hepatology, Guangdong Hospital of TCM, Guangzhou 510120;Guangzhou Overseas Chinese Hospital;Traditional Chinese Medicine University of Guangzhou, China) |
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| Abstract: | CAO Minling;CHI Xiaoling;JIANG Junmin;TANG Yonghuang;ZHOU Yuexiang(Department of Hepatology, Guangdong Hospital of TCM, Guangzhou 510120;Guangzhou Overseas Chinese Hospital;Traditional Chinese Medicine University of Guangzhou, China) |
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| Keywords: | Chronic hepatitis B Tenofovir disoproxil fumarate Resistance Mutation Suboptimal response Affecting factors |
| 本文献已被 CNKI 维普 等数据库收录！ |
