| 胃癌一级亲属血清胃蛋白酶原的测定和意义 |
| |
| 引用本文： | 孟欣颖,于新娟,许倩倩,徐晓娜,董全江,周长宏.胃癌一级亲属血清胃蛋白酶原的测定和意义[J].胃肠病学和肝病学杂志,2019(6):633-636. |
| |
| 作者姓名： | 孟欣颖 于新娟 许倩倩 徐晓娜 董全江 周长宏 |
| |
| 作者单位： | 青岛市市立医院(东院区)保健一科;青岛市市立医院(东院区)中心实验室 |
| |
| 摘 要： | 目的 探讨胃癌一级亲属(first-degree relatives, FDR)血清中胃蛋白酶原(PG)Ⅰ、Ⅱ及PGⅠ/Ⅱ(PGR)的水平变化及其意义。方法入组胃癌FDR共92例,男46例,女46例,年龄(55.4±12.8)岁;均经胃镜和病理学检查证实为慢性胃炎,其中慢性萎缩性胃炎40例,慢性非萎缩胃炎52例。采用酶联免疫吸附法检测血清中PGⅠ、PGⅡ浓度,计算PGR值。结果胃癌FDR中慢性萎缩性胃炎患者血清PGⅠ浓度为(95.15±28.45)μg/L,PGR为11.03±2.43,明显低于慢性非萎缩性胃炎组的(109.66±36.68)μg/L( P= 0.039 )和13.18±4.12(P =0.004)。血清PGⅡ的浓度在各组间差异无统计学意义(P>0.05)。年龄≥60岁组血清PG Ⅰ浓度为(112.44±37.82)μg/L,明显高于年龄<60岁者的(98.02±29.93)μg/L(P=0.046)。不同性别、有无幽门螺杆菌感染对PGⅠ的浓度无明显影响。血清PGⅡ浓度和PGR在不同年龄、性别、有无幽门螺杆菌感染各组间差异无统计学意义(P>0.05)。结论 PGⅠ、PGR降低对胃癌FDR伴有的慢性萎缩性胃炎具有辅助诊断意义。年龄可能会影响血清PGⅠ的水平。
|
| 关 键 词： | 胃癌 一级亲属 胃蛋白酶原 血清 |
Determination and significance of serum pepsinogen in first-degree relatives of gastric cancer |
| |
| MENG Xinying,YU Xinjuan,XU Qianqian,XU Xiaona,DONG Quanjiang,ZHOU Changhong.Determination and significance of serum pepsinogen in first-degree relatives of gastric cancer[J].Chinese Journal of Gastroenterology and Hepatology,2019(6):633-636. |
| |
| Authors: | MENG Xinying YU Xinjuan XU Qianqian XU Xiaona DONG Quanjiang ZHOU Changhong |
| |
| Institution: | (Department of Healthcare,Qingdao Municipal Hospital (East),Qingdao 266071,China;Central Laboratory,Qingdao Municipal Hospital (East),Qingdao 266071,China) |
| |
| Abstract: | MENG Xinying;YU Xinjuan;XU Qianqian;XU Xiaona;DONG Quanjiang;ZHOU Changhong(Department of Healthcare,Qingdao Municipal Hospital (East),Qingdao 266071,China;Central Laboratory,Qingdao Municipal Hospital (East),Qingdao 266071,China) |
| |
| Keywords: | Gastric cancer First-degree relatives Pepsinogen Serum |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
