Effect of 3,4-Benzopyrene on ultrastructure of sinusoidal cells of the liver in adult male rats |
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| Authors: | S. V. Michurina S. I. Kolesnikov S. V. Alisievich I. Yu. Yushchenko |
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| Affiliation: | (1) Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk;(2) Research Center of Medical Ecology, East-Siberian Research Center, Siberian Division of Russian Academy of Medical Sciences, Irkutsk |
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| Abstract: | Reoganization of sinusoidal cells (endotheliocytes, Kupffer cells, and Ito cells) in the liver microregion of male rat liver exposed to 3,4-benzopyrene was studied. Synchronous activation of the lysosome-vacuole systems in Kupffer cells and endotheliocyte indicates cooperation of these cells in detoxification of benzopyrene and its metabolites. Ito cells lose lipid inclusions and actively proliferate; the appearance of intermediate forms between lipocytes and fibroblasts attests to activation of fibrogenesis in the liver. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 12, pp. 696–699, December, 2000 |
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| Keywords: | liver sinusoidal cells endothelicocytes Kupffer cells lipocytes 3,4-benzopyrene |
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