腺苷受体激动剂在豚鼠实验性哮喘中的作用

目的：研究腺苷受体激动剂Ｒ－苯异丙基腺苷对实验性哮喘豚鼠气道阻力、肺顺应性的影响。方法：复制豚鼠实验性哮喘动物模型，给予Ｒ－ＰＩＡ５ｍｇ／ｍｌ的生理盐水雾化吸入，观察气道阻力、肺顺应性的变化，以及肺泡灌洗液中ＮＯＸ、环－磷酸腺苷、环磷酸鸟苷、肿瘤坏死因子（ＴＮＦ）含量的变化。结果：给予Ｒ－ＰＩＡ雾化吸入后较哮喘组气道阻力增加，肺顺生下降，肺泡灌洗液中ＮＯＸ、ＣＡＭＰ、ＣＧＭＰ、ＴＮＦ水平下降，而Ｔ

Effects of inhaling N6-phenyl-2R-isopropyl-adenosine on the experimental asthmatic guinea-pigs

AIM:To evaluate the role of inhaling N 6-phenyl-2R-isopropyl-adenosine (R-PIA) on the airway resistance and pulmonary compliance of experimental asthmatic guinea-pigs. METHODS: Experimental model of asthmatic guinea-pigs were made. Inhaling R-PIA 5 mg/mL( 5 mg R-PIA in 1 mL 0.9% saline). The airway resistance, pulmonary compliance and NO- x, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP),tumor necrosis factor (TNF) in bronchoalveolar lavage fluid (BALF) were observed. RESULTS: Compared with asthma group, after inhaling R-PIA, the airway resistance of experimental asthmatic guinea-pigs increased ( P <0.05), but the pulmonary compliance decreased ( P <0.05). So did the NO- x and cAMP, cGMP in BALF ( P <0.05), TNF in BALF had no change ( P >0 05). CONCLUSION: Inhaling R-PIA could constrict the airway of experimental asthmatic guinea-pigs.