| 瑞香素对小鼠免疫功能的影响 |
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| 引用本文： | 贾正平,冯璞.瑞香素对小鼠免疫功能的影响[J].中国药理学与毒理学杂志,1992,6(3):235-236. |
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| 作者姓名： | 贾正平 冯璞 |
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| 作者单位： | 解放军兰州军区总医院药材科，甘肃省新医药研究所免疫室，解放军兰州军区总医院药材科，解放军兰州军区总医院药材科，解放军兰州军区总医院药材科，甘肃省新医药研究所免疫室 兰州 730050，兰州 730050，兰州 730050，兰州 730050，兰州 730050，兰州 730050 |
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| 摘 要： | <正> 瑞香素(Daphnetin,Dap)系瑞香科植物黄瑞香(Daphne giralaii Nitsche)中的有效单体,化学结构为7,8-二羟基香豆素.实验证明Dap有扩张冠状血管,增加冠状血流,改善心肌代谢作用,并有抑制实验性关节炎,兴奋垂体—肾上腺皮质系统,抗血栓形成,抑制血小板聚集和降血脂功能.临床上对冠心病心绞痛,血栓闭塞性脉管炎和风湿及
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| 关 键 词： | 瑞香素 溶血素 迟发超敏反应 巨噬细胞吞噬 抗体形成 |
Effect of Daphne tin on immune function in mice |
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| JIA Zheng-Ping,FENGPu,ZHAO Yu-Xi,XIE Jing-Wen,XIE Ting-Quan,DU Chun-Xi.Effect of Daphne tin on immune function in mice[J].Chinese Journal of Pharmacology and Toxicology,1992,6(3):235-236. |
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| Authors: | JIA Zheng-Ping FENGPu ZHAO Yu-Xi XIE Jing-Wen XIE Ting-Quan DU Chun-Xi |
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| Institution: | JIA Zheng-Ping,FENGPu,ZHAO Yu-Xi,XIE Jing-Wen,XIE Ting-Quan,DU Chun-XiDepartment of Pharmacy,General Hospital of Lanzhou Command of PLA,Lanzhou 730050,Department of Immunology,Gansu Institute of New Medicine,Lanzhou 730050 |
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| Abstract: | The effect of Daphnetin (Dap) on the immune function was studied in mice. BALB / c mice were injected intraperitoneally with 25, 50 and 100 mg·kg-1 of Dap for 7 d. The results showed that the spleen and thymus weights were significantly reduced, the serum agglutination liter, hemolysin HC50, and anti-SRBC antibody secreted by the spleen cells of the mice immunized with SRBC markedly decreased, and the foot-pad delayed-type hypersensitivity reaction (DTH) was inhibited. Dap 100-400·kg-1 ip for7 d enhanced markedly the peritoneal macrophage phagocytosis in mice.These results suggest that Dap may be an effective immunomodulating agent, which inhibits the humoral and cell-mediated immunity and enhances the macrophage phagocytosis. |
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| Keywords: | Daphnetin hemolysin delayed type hypersensitivity reaction macrophage phagocytosis antibody formation |
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