不同剂量重组葡激酶治疗幼猪急性脑梗死对凝血和纤溶功能的影响

目的：研究重组葡激酶（rSaK)治疗急性脑梗死对血液凝血及纤溶功能的影响。方法：幼猪48头，分为对照组和7个rSaK组（剂量0．4万－6．4万IU/kg)，每组6头，幼猪脑梗死4h后静脉用rSaK，对照组用安慰剂，治疗后30，60，90min测凝血酶原时间（PT），部分凝血活酶时间（APTT），凝血酶时间（TT），纤维蛋白原（Fg)，优球蛋白溶解时间（ELT），血浆纤溶酶原活性（Plg:A),D-二聚体（DD）。结果：rSaK延长PT，APTT，TT，缩短ELT，增加DD，剂量越大越明显，但对Fg,Plg,A影响很小，结论：rSaK 能显著增强纤溶活性，对血液凝血功能影响较小。

Kinetic changes of hemostatic function in swine with acute cerebral infarction treated with recombinant staphylokinase(rSaK)

Objective Observe the changes of hemostatic function in swine with acute cerebral infarction treated with rSaK.Methods 48 swines were divided into 7 rSaK intravenous thrombolysis groups (dosage from 4 000 to 64 000 IU/kg) and a control group,6 swines were available for each group.rSaK in different dosages were used through abdominal venous catheter respectively after the distal part of ICA had been embolized for 4 hours.PT,APTT,TT,Fg,ELT,Plg:A and DD were detected after administration for 30,60,90 minutes.Results rSaK prolonged TT,PT,APTT,increased DD and decreased ELT,the more dosage,the more obviously.rSaK had little influences upon Fg,Plg:A.Conclusion rSaK can enhance fibrinolytic function,but have little influences on blood coagulation.