| 作用机理不同的扩血管药对高K^＋及去甲肾上腺素所致血管收缩的影响 |
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| 引用本文： | 谢笑龙 王隽. 作用机理不同的扩血管药对高K^＋及去甲肾上腺素所致血管收缩的影响[J]. 遵义医学院学报, 1997, 20(4): 5-9 |
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| 作者姓名： | 谢笑龙 王隽 |
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| 作者单位： | 遵义医学院药理学教研室(谢笑龙，黄燮南)，贵阳医学院药学系(王隽) |
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| 摘 要： | 在兔离体胸主动脉条，比较酚妥拉明（Phen），维拉帕米（Ver），forskolin（Fors）和cromakalim（Cro）等4种作用机理不同的扩血管药对高K 及去甲肾上腺素（NA）量效曲线的影响。结果表明，Phen使NA星效曲线平行右移是其区别于其它扩血管药的特点；Ver抑制高K -收缩明显大于其对NA-收缩的抑制。Fors和Cro抑制NA收缩的强度则远较抑制高K 一收缩为大，但Cro的IC50值明显大于Fors。
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| 关 键 词： | 酚妥拉明 维拉帕米 foskolin cromakalim高K~ 去甲肾上腺素 胸主动脉条 |
Effcts of the vasodilators with different mechanisms of action on the contractions induced by high K~ and noradrenaline in isolated rabbit aorta |
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| Xie Xiaolong, Huang Xienan, Wang Jun. Effcts of the vasodilators with different mechanisms of action on the contractions induced by high K~ and noradrenaline in isolated rabbit aorta[J]. Acta Academiae Medicine Zunyi, 1997, 20(4): 5-9 |
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| Authors: | Xie Xiaolong Huang Xienan Wang Jun |
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| Abstract: | The effects of phentolamine (Phen), verapamil (Ver), forskoline (Fors ) andcromakalim (Cro) on the dose-response curves for KCl or noradrenaline (NA) were comparedin rabbit aortic strips. The results suggested that, being different from the other three drugs,Phen shifted the dose-response curves for NA to the right in a parallel fashion. The inhibitingeffect of Ver on KCl-induced contraction was more Potent than that on NA-induced contraction.In contrast with Ver, the inhibiting effects of Fors and Cro on NA-induced contraction, weremere potent than that on KCl-induced contraction, hut the IC50 of Cro was higher significantlythan that of Fors. |
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| Keywords: | phentolamine verapamil forskolin cromakalim high K~ noradrenaline thoracic aorta strip |
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