The role of fibrin in the mechanism of vascular permeability

Summary The effect of nicotinic acid and heparin on vascular permeability was studied in dogs. The state of vascular permeability was determined by the rate of Evans blue elimination from the blood. Nicotinic acid and heparin had a marked intensifying effect on the fibrinolytic activity of the blood. Notwithstanding the intensified fibrinolysis, no disturbance of the vascular permeability was detected. This casts doubt both on the literature data concerning the presence of fibrin film on the internal surface of normal vessels and on the supposition concerning the fibrin participation in the mechanism of normal vascular permeability.Department of Pathological Physiology (Head, Professor I. A. Oivin), Kuban Medical Institute(Presented by Active Member AMN SSSR A. E. Braunshtein) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 54, No. 10, pp. 45–47, October, 1962