| 缺氧/复氧对兔肾动脉内皮依赖性舒张功能的影响 |
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| 引用本文： | 丰贵文,于立新,龙村. 缺氧/复氧对兔肾动脉内皮依赖性舒张功能的影响[J]. 南方医科大学学报, 2003, 23(9): 925-928 |
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| 作者姓名： | 丰贵文 于立新 龙村 |
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| 作者单位： | 1. 第一军医大学南方医院肾移植科,广东,广州,510515
2. 协和医科大学阜外心血管病医院麻醉与体外循环实验室,北京,100037 |
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| 摘 要： | 目的探讨缺氧/复氧对肾动脉内皮依赖性一氧化氮(NO)和内皮衍性超极化因子(EDHF)途径舒张功能的影响。方法采用器官槽法,以兔肾动脉环为研究对象,首先抑制PGI2舒张途径,然后再分别抑制NO和EDHF舒张途径,对给与血管环以缺氧/复氧处理,观察缺氧/复氧分别对NO和EDHF舒张途径的影响。结果缺氧/复氧使NO途径的内皮依赖性舒张功能减退,而缺氧/复氧对EDHF途径的内皮依赖性舒张功能无变化。结论缺氧/复氧导致兔肾血管内皮衍性NO途径的舒张损伤,而对EDHF途径的舒张无影响。
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| 关 键 词： | 肾动脉 兔 缺氧/复氧 一氧化氮 内皮衍性超极化因子 |
| 文章编号： | 1000-2588(2003)09-0925-04 |
| 修稿时间： | 2002-10-22 |
Effect of hypoxia-reoxygenation on endothelium-dependent relaxation of rabbit renal artery |
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| FENG Gui-wen ,YU Li-xin ,LONG Cun. Effect of hypoxia-reoxygenation on endothelium-dependent relaxation of rabbit renal artery[J]. Journal of Southern Medical University, 2003, 23(9): 925-928 |
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| Authors: | FENG Gui-wen YU Li-xin LONG Cun |
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| Affiliation: | FENG Gui-wen 1,YU Li-xin 1,LONG Cun 21 Department of Kidney Transplantation,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China, 2 Laboratory of Anesthesia and in vitro Circulation,Fuwai Cardiovascular Hospital,Xiehe Medical University,Beijing 100037,China |
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| Abstract: | Objective To investigate the effect of hypoxia-reoxygenation on of endothelium-dependent NO and endotheli-um-derived hyperpolarizing factor (EDHF) relaxation of. Methods The organ chamber technique was employed to study rab-bit renal artery rings. By inhibiting the PGI 2 relaxation pathway with hypoxia-reoxygenation of the renal artery rings, followed by inhibition of NO and EDHF relaxation pathways respectively, the effects of hypoxia-reoxygenation on NO and EDHF re-laxation were observed. Results Hypoxia-reoxygenation decreased the endothelial NO relaxation of rabbit renal rings, but the endothelial EDHF relaxation. Conclusion Hypoxia-reoxygenation may injure endothelium-derived NO relaxation, but not the endothelium-derived EDHF relaxation of rabbit renal rings. |
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| Keywords: | renal artery rabbit hypoxia-reoxygenation nitric oxide endothelium-derived hyperpolarizing factor |
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