| 帕金森病大鼠中枢神经一氧化氮合成酶活性研究 |
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| 引用本文： | 徐建华,吴斌,陈达伟,孙滢. 帕金森病大鼠中枢神经一氧化氮合成酶活性研究[J]. 海军医学杂志, 2011, 32(4): 245-248 |
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| 作者姓名： | 徐建华 吴斌 陈达伟 孙滢 |
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| 作者单位： | 1. 海军医学研究所,上海,200433
2. 中国军事医学科学院 |
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| 摘 要： | 目的 通过对帕金森病(Parkinson's disease,PD)大鼠中枢神经系统一氧化氮合成酶(NOS)3种同工酶的活性变化的研究,探讨帕金森病发病的可能因素和机制.方法 用6-羟多巴胺(6-OHDA)毁损单侧黑质建立大鼠向健侧旋转运动的帕金森病动物模型;采用分光光度法检测神经元型一氧化氮合成酶(nNOS)、内皮型...
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| 关 键 词： | 帕金森病 中枢神经 一氧化氮合成酶 |
Study on the activity of nitric oxide synthetase in the central nervous system of the rat with Parkinson' s disease |
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| XU Jian-hua,WU Bin,CHEN Da-wei,SUN Ying. Study on the activity of nitric oxide synthetase in the central nervous system of the rat with Parkinson' s disease[J]. Journal of Navy Medicine, 2011, 32(4): 245-248 |
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| Authors: | XU Jian-hua WU Bin CHEN Da-wei SUN Ying |
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| Affiliation: | XU Jian-hua,WU Bin,CHEN Da-wei,SUN YingNaval Medical Research Institute,Shanghai 200433,China |
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| Abstract: | Objective To explore possible mechanism and pathogenic factors involved through studying changes in the activity of 3 isoenzymes of nitric oxide synthetase(NOS) in the central nervous system of the rat with Parkinson's disease(PD).The rat model of PD was developed with the injection of 6-hydroxy dopamine(6-OHDA)into the striatum.Changes in the activity of neuronal nitric oxide synthetase(nNOS),endothelia nitric oxide synthetase(eNOS) and induced nitric oxide synthetase(iNOS)were monitored by spectrophotomet... |
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| Keywords: | Parkinson's disease Central nervous system Nitric oxide synthetase |
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