| 胶质母细胞瘤115例临床病理分析 |
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| 引用本文： | 周福安,冯晨,张巍. 胶质母细胞瘤115例临床病理分析[J]. 新疆医科大学学报, 2011, 34(6): 598-601 |
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| 作者姓名： | 周福安 冯晨 张巍 |
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| 作者单位： | 1. 新疆医科大学第一附属医院病理科,新疆,乌鲁木齐,830000
2. 乌鲁木齐市友谊医院病理科,新疆,乌鲁木齐,830000 |
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| 摘 要： | 目的 探讨胶质母细胞瘤临床病理特点、免疫表型、影像学特点、诊断及鉴别诊断。方法对115例胶质母细胞瘤标本进行临床资料统计,应用HE染色、免疫组化等方法进行病理学特征观察,CT和MR检查分析其影像特点。结果位于大脑半球的胶质母细胞瘤临床表现主要为头痛、呕吐、癫痫发作,肿瘤组织学显示瘤细胞弥漫分布,核异型性明显,血管明显增生,伴有出血和坏死,坏死灶周围瘤细胞常排列呈栅栏状。免疫组化显示胶质纤维酸性蛋白(GFAP)和波形蛋白(vimentin)均呈强弱不等的阳性,Ki-67表达较高,阳性细胞数平均为34.3%,所有病例血管内皮细胞均表达CD34,P53的阳性率为25.2%。CT和MR检查示界限不清的占位性病变常伴有出血、坏死和囊性变,增强扫描呈不规则环状强化。结论胶质母细胞组织形态具有一定的特征性;其影像学表现主要为水肿、出血、坏死和囊性变。
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| 关 键 词： | 胶质母细胞瘤 病理学特征 免疫组织化学 影像学 鉴别诊断 |
Clinicopatholigical analysis of 115 glioblastoma |
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| ZHOU Fu-an,FENG-Chen,ZHANG-Wei. Clinicopatholigical analysis of 115 glioblastoma[J]. Journal of Xinjiang Medical University, 2011, 34(6): 598-601 |
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| Authors: | ZHOU Fu-an FENG-Chen ZHANG-Wei |
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| Affiliation: | ZHOU Fu-an,FENG-Chen,ZHANG-Wei(Dpartment of Pathology,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China) |
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| Abstract: | Objective To investigate the clinicopathologic features,immunophenotypes and image features in 115 cases of glioblastoma.Methods The clinical and pathological data of glioblastoma were collected and studied with H.E.and immunohistochemical staining.The image features of CT and MR were also analyzed.Results The clinical symptoms of the cases were headache,vomiting and epileptic seizure.Histopathologically,the tumor cells were distributed diffusely with marked nuclear atypia and brisk mitotic activity.Promine... |
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| Keywords: | glioblastoma pathologic diagnosis immunohistochemistry image features differential diagonosis |
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