| 非小细胞肺癌组织中COX-2表达及其与微血管和微淋巴管密度的关系 |
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| 引用本文： | 张焕,杨丽丽,房新志. 非小细胞肺癌组织中COX-2表达及其与微血管和微淋巴管密度的关系[J]. 新疆医科大学学报, 2011, 34(6): 591-594,597 |
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| 作者姓名： | 张焕 杨丽丽 房新志 |
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| 作者单位： | 新疆医科大学附属肿瘤医院病理科,新疆,乌鲁木齐,830011 |
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| 摘 要： | 目的 探讨非小细胞肺癌组织中COX-2表达的临床病理学意义,及其与微血管密度(MVD)和微淋巴管密度(MLD)的关系。方法采用免疫组化PV-9000法检测80例非小细胞肺癌组织中COX-2的表达,同时标记CD34和D2-40,分别检测非小细胞肺癌组织中微血管和微淋巴管密度。结果 80例非小细胞肺癌组织中COX-2的阳性表达率为88.75%(71/80),COX-2的表达与患者性别、肿瘤位置、组织学类型无关(P>0.05),而与肿瘤大小、组织学分级、淋巴结转移及其临床病理分期密切相关(P<0.05);COX-2表达阳性者的MVD和MLD均明显高于COX-2表达阴性者(P<0.05)。结论 COX-2可能通过促进肿瘤的血管和淋巴管形成而参与非小细胞肺癌细胞的浸润和转移。
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| 关 键 词： | 肺肿瘤 COX-2 微淋巴管密度 微血管密度 |
Correlation between COX-2 expression and microvascular with microlymphatic density in non-small cell lung cancer |
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| ZHANG Huan,YANG Li-li,FANG Xin-zhi. Correlation between COX-2 expression and microvascular with microlymphatic density in non-small cell lung cancer[J]. Journal of Xinjiang Medical University, 2011, 34(6): 591-594,597 |
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| Authors: | ZHANG Huan YANG Li-li FANG Xin-zhi |
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| Affiliation: | ZHANG Huan,YANG Li-li,FANG Xin-zhi,et al(Deprtment of Pathology,Third Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China) |
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| Abstract: | Objective To explore the expression of cyclooxygenase-2(COX-2) in non-small cell lung cancer and its correlations with microvascular density(MVD) and microlymphatic density(MLD).Methods The expression of COX-2,MVD and MLD were detected by PV-9000 immunohistochemistrical method in 80 cases of non-small cell lung cancer.Results In the non-small cell lung cancer,the positive rate of COX-2 was 88.75 %.The over expression of COX-2 was related with tumor size and lymphatic metastasis(P<0.05).The MLD with positive... |
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| Keywords: | COX-2 |
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