| 肝靶向氧化苦参碱毫微粒制备工艺研究 |
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| 引用本文： | 袁海龙,赵艳玲,杨贤曹,肖小河,蔡光明,贺承山.肝靶向氧化苦参碱毫微粒制备工艺研究[J].中药新药与临床药理,2004,15(1):54-56. |
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| 作者姓名： | 袁海龙 赵艳玲 杨贤曹 肖小河 蔡光明 贺承山 |
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| 作者单位： | 中国人民解放军第302医院药学部,北京,100039 |
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| 基金项目： | 国家中医药管理局科研项目 |
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| 摘 要： | 目的优选肝靶向氧化苦参碱毫微粒的制备工艺.方法采用乳化聚合法制备,以毫微粒的包封率作为考察指标,系统观察法优化最佳制备工艺.结果采用该制备工艺得到的毫微粒粒子均匀圆整,平均粒径在100～200nm之间,包封率较高,平均为87.06%.结论该工艺稳定可行,可作为肝靶向氧化苦参碱毫微粒生产工艺的参考.
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| 关 键 词： | 氧化苦参碱 毫微粒 肝靶向 中药制剂工艺 |
| 文章编号： | 1003-9783(2004)01-0054-03 |
| 修稿时间： | 2003年7月1日 |
Studies on the Process of Liver-targeted Oxymatrine Nanoparticle |
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| YUAN Hailong,ZHAO Yanling,YANG Xiancao,XIAO Xiaohe,CAI Guangming,HE Chengshan.Studies on the Process of Liver-targeted Oxymatrine Nanoparticle[J].Traditional Chinese Drug Research & Clinical Pharmacology,2004,15(1):54-56. |
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| Authors: | YUAN Hailong ZHAO Yanling YANG Xiancao XIAO Xiaohe CAI Guangming HE Chengshan |
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| Abstract: | Objective To optimize the process for preparing liver- targeted oxymatrine nanoparticles (LTON).Methods LTON was prepared with emulsive polymerization method.Inclusion rate and outward appearance of the nanoparticles were used as the optimized indexes.Results LTON was uniform and round; the average diameter ranged from 100 to 200 nm and the inclusion ratio was 87.06 % .Conclusion This process is stable and feasible. |
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| Keywords: | Oxymatrine Nanoparticle Liver targeted Pharmaceutical technology(TCD) |
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