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| nm23-H1基因对舌癌细胞株化疗敏感性的影响体外实验 | |
| 引用本文： | 陈绍维,李唐新,陈伟辉.nm23-H1基因对舌癌细胞株化疗敏感性的影响体外实验[J].广东牙病防治,2002,10(4):245-247. |
| 作者姓名： | 陈绍维 李唐新 陈伟辉 |
| 作者单位： | 1. 中山大学附属第二医院口腔科,广东,广州,510120 2. 中山大学光华口腔医学院 3. 福建医科大学附属协和医院 |
| 基金项目： | 国家自然基金,39870746 |
| 摘 要： | 目的：通过nm23-H1的转化及导入BcaCD885细胞株，观察nm23-H1对BcaCD885细胞株化疗敏感性的影响。方法：完成细胞培养和基因转染后，MTT法观察nm-23-H1对BcaCD885化疗敏感性影响。结果：转染前BcaCD885细胞株对ADM、5－FU、MTX的化疗敏感性无显著差异。但转染后的BcaCD885细胞株对CDDP明显增敏。结论：nm23-H1可能通过特异笥地影响细胞内的能量交换过程来达到对CDDP化疗增敏的效果。 |
| 关 键 词： | nm23－H1基因 舌癌细胞株 化疗敏感性 体外实验 基因转染 细胞培养 |
The Influence of nm23-H1 to Chemo-sensitivity in Oral Carcinoma Cell Lines in Vitro |
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| Chen Shaowei,et al..The Influence of nm23-H1 to Chemo-sensitivity in Oral Carcinoma Cell Lines in Vitro[J].Journal of Dental Prevention and Treatment,2002,10(4):245-247. | |
| Authors: | Chen Shaowei |
| Institution: | Chen Shaowei,et al. The Department of stomotology,2th Hospital,Sun Yat-sen University,Guangzhou 510120 |
| Abstract: | Objective To find out whether nm23 - H1 could affect the chemo- sensitivity of BcaCD885 cell lines by transfecting nm23 - H1 into the BcaCD885 cell lines. Methods Nm23 - HI was transfected into BcaCD885 cell lines and the change of chemo - sensitivity was assessed by MTT. Result The transfected BcaCD885 cell line is more sensitive to CDDP. Conclusion Nm23 - H1 can enhance chemo- sensitivity to CDDP significantly perhaps by affecting the exchange of the energy in cells. |
| Keywords: | nm23 - HI BcaCD885 cell lines chemo - sensitivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |