闭经患者的细胞遗传学分析

分析闭经患者的异常核型形成的可能原因及其与临床症状的关系.方法:对78例闭经患者进行外周血染色体标本作常规分析.结果:共发现染色体异常28例,占全部被检者35.90%.其中原发性闭经46 例,检出异常核型25例(54.35%);继发性闭经32例,检出异常核型3例(9.38%).结论:对原发性闭经患者应常规行外周血染色体检查,以明确闭经的原因 ,及早对症治疗;继发性闭经尤其是25岁以下的患者也应及时进行染色体检查.

The cytogenetics analysis of 78 patients with amenorrhea

Objective:To analye the important cause of abnormal karyotype forming of patients with amenorrhea and the relationship between abnormal karyotype and clinical symptoms.Methods:The blood chromosome specimen of 78 cases with amenorrhea were analysed using standand technique.Results:Among 78 cases with amenorrhea,28 cases with abnormal chromosome were detected,accounting for 35.90% within all cases.Twenty five(54.35%) of 46 cases with primary amenorrea were abnormal karyotype;while 3(9.38%) of 32 cases with secondary amenorrea were abnormal karyotype.Conclusions:The cases with primary amenorrhea should be taken for a routine chromosome examination and early expectant treatment.Chromosome examination should also be taken in cases with secondary amenorrea in time,especially under the age of 25.