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Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis |
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| Authors: | Saeki Yukihiko Okita Yasutaka Igashira-Oguro Eri Udagawa Chikako Murata Atsuko Tanaka Takashi Mukai Jyunji Miyazawa Keiji Hoshida Yoshihiko Ohshima Shiro |
| Affiliation: | 1.Rheumatology & Allergology, NHO Osaka Minami Medical Center, Kidohigashi-machi, Kawachinagano, Osaka, 586-8521, Japan ;2.Department of Clinical Research, NHO Osaka Minami Medical Center, 2-1 Kidohigashi-machi, Kawachinagano, Osaka, 586-8521, Japan ;3.Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Yamada-oka, Suita, Osaka, 565-0871, Japan ;4.Molecular Chemistry, Faculty of Pharmacology, Osaka Ohtani University, Nishikiori-kita, Tondabayashi, Osaka, 584-8540, Japan ;5.Department of Pharmacy, Izumi-City General Hospital, Wake-Cho, Izumi City, Osaka, 594-0072, Japan ;6.KISSEI Pharmaceutical CO., L.T.D, Yoshino, Matsumoto City, Nagano Prefecture, 399-8710, Japan ;7.Pathology, NHO Osaka Minami Medical Center, Kidohigashi-machi, Kawachinagano, Osaka, 586-8521, Japan ; |
| Abstract: | Clinical Rheumatology - To evaluate the ability of geldanamycin to modulate two opposing TNFα/TNFR1-triggered signals for inflammation and cell death. The effects of geldanamycin on... |
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