HLA-DR3- and HLA-DR7-Restricted T-Cell Hyporesponsiveness to Gluten Antigen: A Clue to the Aetiology of Coeliac Disease? |
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Authors: | H. SCOTT H. HIRSCHBERG E. THORSBY |
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Affiliation: | Tissue Typing Laboratory, Rikshospitalet, The National Hospital, Oslo, Norway |
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Abstract: | Coeliac disease (CD) is strongly associated with the human class-II HLA determinants HLA-DR3 and -DR7. We investigated the relative frequency of gluten-reactive T cells from DR3- or DR7-positive. CD patients and healthy controls who were heterozygous at the DR locus. We found a consistently and significantly lower frequency of gluten-reactive T cells when the antigen was presented by monocytes in conjunction with DR3 or DR7 than in conjunction with the other DR determinant of the T-cell donor. In contrast, the frequency of reactive T cells in these donors to other antigens was not reduced in conjunction with DR3 or DR7. These results indicate a specific immunoregulatory function associated with class-II HLA molecules. The reduced frequency of gluten-reactive T cells in association with HLA-DR3 or -DR7 may be directly involved in the development of CD. |
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