罗格列酮对自发性高血压大鼠肾脏保护作用的形态学研究

目的：观察自发性高血压大鼠（SHR）肾脏形态学改变特点，评价罗格列酮对SHR大鼠肾脏形态学改变的预防或保护作用。方法：24只SHR大鼠随机分为观察组与对照组。罗格列酮为观察药，溶于饮水中，实验期8周。实验结束时取大鼠肾脏标本，分别采用光镜和电镜观察。结果：罗格列酮观察组血压［(162±4)mmHg］比对照组［(184±3)mmHg］明显降低（P<0.05），肾脏在光镜和电镜下显示SHR大鼠系膜细胞增生、基底膜增厚、足突融合等异常改变，观察组肾小球系膜细胞和系膜基质无明显增生，肾小球系膜区无明显扩大。结论：罗格列酮可以预防或减轻SHR大鼠肾脏形态学损伤，具有一定肾脏保护作用。

Protective effects of Rosiglitazone on morphologic injuries of kidney in spontaneously hypertensive rats

Objective To observe the morphologic changes of the kidneys of spontaneously hypertensive rats (SHR) and to estimate if Rosiglitazone can prevent or protect the morphologic changes of SHR. Methods 24 SHR rats were randomly divided into Rosiglitazone group and control group. Rosiglitazone was put into the drinking water. The observing time was 8 weeks.In the end of the observation,the kidney specimens were obtained.The morphologic changes were observed under light and electron microscopes. Results Compared with control group,Rosiglitazone could reduce the blood pressure greatly (P<0.05);rosiglitazone group: (162±4) mmHg,control group:(184±3) mmHg.There were some kinds of morphologic injures such as mesangial cell proliferation and podocytic fusion appeared in the kidneys of SHR and rosiglitazone could prevent or attenuate those morphologic changes. Conclusion Rosiglitazone can prevent or attenuate the morphologic injuries of kidneys of SHR and has protective effects on kidney.