可溶性生长刺激表达基因2蛋白对免疫检查点抑制剂相关心肌炎预后的预测价值

目的:探讨可溶性生长刺激表达基因2蛋白(soluble growth stimulation expressed gene 2 protein,sST2)对免疫检查点抑制剂相关心肌炎(immune checkpoint inhibitor-associated myocarditis,ICIAM)患者预后的预测价值.方...

Prediction value of sST2 for the prognosis of patients with immune checkpoint inhibitor-associated myocarditis

Objective: To investigate the prognostic value of soluble growth stimulation expressed gene 2 protein (sST2) in patients with immune checkpoint inhibitor-associated myocarditis (ICIAM).Methods: From January 1, 2019 to December 31, 2020, 19 patients with ICIAM were selected from Cardio-oncology multidisciplinary team of Zhongshan Hospital, Fudan University. According to the prognosis, they were divided into the survival group (n=15) and the death group (n=4). Receiver operating characteristic (ROC) curve was used to analyze the predictive value of sST2 level for prognosis.Results: The peak concentration of sST2 in the death group was higher than that in the survival group during the treatment (156.50[91.60, 410.60] ng/mL vs 54.65[18.20, 97.40] ng/mL, P=0.014), and there was no significant difference in other indexes. The peak concentration of sST2 was negatively correlated with survival (r=-0.683, P=0.010). ROC analysis showed that when sST2 level was 87.5 ng/mL, area under the curve (AUC) was 0.967, sensitivity was 90.0%, and specificity was 100.0%.Conclusions: sST2 could predict the prognosis of patients with ICIAM, and could help to make and improve the treatment of patients with ICIAM.