乌司他丁治疗西宁地区急性肺损伤的临床研究

目的：观察乌司他丁对西宁地区急性肺损伤（ALI）的疗效。方法：将50例急性肺损伤患者,随机分为两组,实验组25例,对照组25例,所有患者均行ICU综合治疗,实验组加用乌司他丁,观察两组患者呼吸频率（RR）、血气指标、急性生理和慢性健康状况评分Ⅱ（APACHEⅡ评分）、急性呼吸窘迫综合征（ARDS）发生率及死亡率变化。结果：治疗第7天实验组患者RR、APACHEⅡ评分、动脉血氧分压（PaO2）、氧合指数（PaO2/FiO2）较对照组明显改善（P〈0.05）,两组间ARDS发生率及死亡率比较差异均有统计学意义（P〈0.05）。结论：乌司他丁能显著改善西宁地区急性肺损伤患者的氧合,降低ARDS发生率,对改善预后有积极的作用。

Treatment Effect of Ulinastatin on Acute Lung Injury in Xining

Objective：To observe treatment effects of ulinastatin on acute lung injury（ALI） in Xining area.Methods：50 patients with acute lung injury were randomly divided into two groups,the experimental group and control group of 25 each,all patients underwent comprehensive ICU treatment;the experimental group received Ulinastatin（300 000U ＋ normal saline intravenous infusion,2/day for 7-10 days） on the basis of ICU.The respiratory rate（RR）,blood gas,acute physiology and chronic health evaluation II（APACHE Ⅱ） score,morbidity and mortality of ARDS were recorded and analyzed.Results：The RR,APACHE Ⅱ score,PaO2,PaO2/FiO2 were significantly improved on day 7 in experimental group compared with control group（P0.05）.And there was a difference in mortality and morbidity of ARDS between two groups（P0.05）.Conclusions：Treatment with Ulinastatin can significantly improve oxygenation in patients with acute lung injury,and reduce the incidence of ARDS in Xining.