pten、p53在子宫内膜癌中的表达及意义

目的：探讨子宫内膜癌组织中pten、p53蛋白表达，以及与子宫内膜癌发生、发展及预后的关系。方法：应用免疫组化SP法检测20例子宫内膜癌组织中pten、p53蛋白的表达。结果：子宫内膜癌组织中pten蛋白的失表达主要局限于子宫内膜样腺癌，占60％，5例浆液性癌中则未见pten的失表达，pten失表达在这两组肿瘤间的差异有显著性（P=0．006），p53蛋白过表达在子宫内膜样腺癌中占26．7％，在浆液性癌中为80％，两组间差异有极显著性（P=0．001）。结论：pten、p53蛋白的表达与子宫内膜癌的发生相关。用免疫组化法检测pten的表达缺失及p53的过表达是诊断子宫内膜癌及癌前病变的有价值的分子标记物。

Study on the expressions of pten and p53 in endometrial carcinoma and their significance

Objective:To investigate the relationship of the expressions of protein pten and protein p53 in the occurrence,development and prognosis of endometrial carcinoma ( EC). Methods:The expressions of protein pten and protein p53 in 20 endometrial adenocarcinomas were examined by SP immunohistochemical method. Results:In the endometrial carcinoma tela,the lack of expression of protein pten existed in endometrioid adenocarcinoma mainly,which accounted for 60 per cent. In 5 serous carcinoma cases, however, the lack of expression of protein pten was not seen. The lack of expression of protein pten was significant difference between the two groups(P=0.006).The over-expression of protein p53 covered 26.7 per cent in endometrioid adenocarcinoma while covered 80 per cent in serous carcinoma.The differences between the two groups were significant(P=0.001). Conclusion:The expressions of protein pten and protein p53 are relevant to the occurrence of endometrial carcinoma. The expression loss of protein pten and over-expression of protein p53 the detected by SP immunohistochemical method are likely to be valuable labelled molecules used to diagnose endometrial carcinoma and its precancerous lesion.